methyl N-acetyl-1-methyl-5-nitro-L-histidinate

Base Information

• Chemical Name: methyl N-acetyl-1-methyl-5-nitro-L-histidinate
• CAS No.: 107089-37-2
• Molecular Formula: C₁₀H₁₄N₄O₅
• Molecular Weight: 270.245
• Mol file: 107089-37-2.mol

Synonyms:Na-Acetyl-Nt-methyl-5-nitro-L-histidinemethyl ester

Chemical Property of methyl N-acetyl-1-methyl-5-nitro-L-histidinate

Chemical Property:

• Vapor Pressure: 4.69E-12mmHg at 25°C
• Boiling Point: 547.8°Cat760mmHg
• Flash Point: 285.1°C
• Density: 1.42g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl N-acetyl-1-methyl-5-nitro-L-histidinate

There total 5 articles about methyl N-acetyl-1-methyl-5-nitro-L-histidinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + Nα-Acetyl-4-nitrohistidine methyl ester (41429-88-3) → N3-Methyl-Nα-acetyl-4-nitrohistidine methyl ester (107089-37-2)

Guidance literature:

In methanol; diethyl ether; for 16h; Ambient temperature;

DOI:10.1002/jhet.5570230351

Reference yield: 17.0%

Nα-Acetyl-4-nitrohistidine methyl ester (41429-88-3) + methyl iodide (74-88-4) → N1-Methyl-Nα-acetyl-4-nitrohistidine methyl ester (107089-38-3) + N3-Methyl-Nα-acetyl-4-nitrohistidine methyl ester (107089-37-2)

Guidance literature:

With potassium hydroxide; In methanol; for 37h; Heating;

DOI:10.1002/jhet.5570230351

Reference yield:

L-Histidine (71-00-1) → N3-Methyl-Nα-acetyl-4-nitrohistidine methyl ester (107089-37-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / acetic acid / 0.05 h / 100 °C

2: 63 percent / conc. H₂SO₄, fuming HNO₃ / 2 h / 40 - 45 °C

3: 5.8 g / SOCl₂ / 8 h / Ambient temperature

4: 33 percent / methanol; diethyl ether / 16 h / Ambient temperature

With thionyl chloride; sulfuric acid; nitric acid; In methanol; diethyl ether; acetic acid;

DOI:10.1002/jhet.5570230351

upstream raw materials:

diazomethane

N^α-Acetyl-4-nitrohistidine methyl ester

methyl iodide

L-Histidine