Propanoic acid, 2-[[4-(aminomethyl)phenyl]thio]-2-methyl-, 1,1-dimethylethyl ester, hydrochloride

Base Information

• Chemical Name: Propanoic acid, 2-[[4-(aminomethyl)phenyl]thio]-2-methyl-, 1,1-dimethylethyl ester, hydrochloride
• CAS No.: 867314-37-2
• Molecular Formula: C15H23NO2S.ClH
• Molecular Weight: 317.88
• Mol file: 867314-37-2.mol

Synonyms:

Chemical Property of Propanoic acid, 2-[[4-(aminomethyl)phenyl]thio]-2-methyl-, 1,1-dimethylethyl ester, hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanoic acid, 2-[[4-(aminomethyl)phenyl]thio]-2-methyl-, 1,1-dimethylethyl ester, hydrochloride

There total 1 articles about Propanoic acid, 2-[[4-(aminomethyl)phenyl]thio]-2-methyl-, 1,1-dimethylethyl ester, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

2-(4-cyanophenylsulfanyl)-2-methyl-propionic acid tert-butyl ester (867314-36-1) → 2-[4-(aminomethyl)-phenylsulfanyl]-2-methyl-propionic acid tert-butylester hydrochloride (867314-37-2)

Guidance literature:

2-(4-cyanophenylsulfanyl)-2-methyl-propionic acid tert-butyl ester; With N,N-diethylaniline borane; In tetrahydrofuran; at 72 ℃; for 3h;

With hydrogenchloride; methanol; at 20 ℃;

With hydrogenchloride; In tert-butyl methyl ether; isopropyl alcohol; at 20 - 47 ℃; for 2h;

Reference yield: 96.0%

2-[4-(aminomethyl)-phenylsulfanyl]-2-methyl-propionic acid tert-butylester hydrochloride (867314-37-2) + N-methyl-2-imidazolcarboxaldehyde (13750-81-7) → tert-butyl-2-methyl-2-{[4-({[(1-methyl-1H-imidazol-2-yl)methyl]amino}methyl)phenyl]thio}-propanoate

Guidance literature:

2-[4-(aminomethyl)-phenylsulfanyl]-2-methyl-propionic acid tert-butylester hydrochloride; With sodium hydroxide; In water;

N-methyl-2-imidazolcarboxaldehyde; In methanol; at 20 ℃; for 2h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.0833333h;

Reference yield: 90.0%

2-[4-(aminomethyl)-phenylsulfanyl]-2-methyl-propionic acid tert-butylester hydrochloride (867314-37-2) + cyanomethyl bromide (590-17-0) → tert-butyl 2-[(4-{[(cyanomethyl)amino]methyl}phenyl)thio]-2-methylpropanoate (882871-71-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

2-(4-cyanophenylsulfanyl)-2-methyl-propionic acid tert-butyl ester

Downstream raw materials:

2-[[4-[[(2-methoxyethyl)amino]methyl]phenyl]thio]-2-methyl-propionic acid tert-butyl-ester

tert-butyl-2-methyl-2-({4-[(prop-2-in-1-ylamino)methyl]phenyl}thio)propanoate

tert-butyl 2-[(4-{[(cyanomethyl)amino]methyl}phenyl)thio]-2-methylpropanoate

tert.-butyl-2-[(4-{[(6-chloropyrimidin-4-yl)amino]methyl}phenyl)thio]-2-methylpropanoate