2-Pentanone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Base Information

• Chemical Name: 2-Pentanone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
• CAS No.: 86864-59-7
• Molecular Formula: C11H24O2Si
• Molecular Weight: 216.396
• European Community (EC) Number: 964-935-4
• Nikkaji Number: J491.572K
• Mol file: 86864-59-7.mol

Synonyms:5-[(tert-butyldimethylsilyl)oxy]pentan-2-one;86864-59-7;5-[tert-butyl(dimethyl)silyl]oxypentan-2-one;5-((tert-butyldimethylsilyl)oxy)pentan-2-one;SCHEMBL875754;HYMOZAQHSDGTIS-UHFFFAOYSA-N;AKOS025393574;SS-4875;5-(tert-Butyl-dimethyl-silanyloxy)-pentan-2-one;EN300-9062725

Chemical Property of 2-Pentanone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 216.154556538
• Heavy Atom Count: 14
• Complexity: 192

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)CCCO[Si](C)(C)C(C)(C)C

Technology Process of 2-Pentanone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

There total 1 articles about 2-Pentanone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxybutanoic acid (591-81-1) + tert-butyldimethylsilyl chloride (18162-48-6) → 5-((tert-butyldimethylsilyl)oxy)pentan-2-one (86864-59-7)

Guidance literature:

With triethylamine; In chloroform; at 0 ℃; for 3h;

Reference yield: 70.0%

Triphenylmethanesulfenamide (38499-08-0) + 5-((tert-butyldimethylsilyl)oxy)pentan-2-one (86864-59-7) → 5-<(tert-Butyldimethylsilyl)oxy>-2-pentanone Tritylsulfenimine (86864-31-5)

Guidance literature:

With pyridinium p-toluenesulfonate; magnesium sulfate; In dichloromethane; for 7h; Ambient temperature;

DOI:10.1021/jo00168a031

Reference yield: 65.0%

(2-bromobenzyl)triphenylphosphonium bromide (36901-75-4) + 5-((tert-butyldimethylsilyl)oxy)pentan-2-one (86864-59-7) → (5-(2-bromophenyl)-4-methylpent-4-enyloxy)(tertbutyl)dimethylsilane

Guidance literature:

(2-bromobenzyl)triphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 1h; Inert atmosphere;

5-((tert-butyldimethylsilyl)oxy)pentan-2-one; In tetrahydrofuran; hexane; at 0 - 115 ℃; for 18h; Inert atmosphere;

DOI:10.1002/adsc.201500317

upstream raw materials:

4-hydroxybutanoic acid

tert-butyldimethylsilyl chloride

Downstream raw materials:

5-<(tert-Butyldimethylsilyl)oxy>-2-pentanone Tritylsulfenimine

(6-Benzenesulfinyl-4-methyl-hexa-4,5-dienyloxy)-tert-butyl-dimethyl-silane

(Z,S_S,2S,3R)-3-[2-(tert-butyldimethylsilyloxy)ethyl]-4-methyl-5-(N-methyl-S-phenylsulfonimidoyl)-2-(tert-butylsulfonylamino)pent-4-enoic acid ethyl ester

(4,6-dimethyl-hepta-4,5-dienyl)-(2-iodo-phenyl)-amine