2-Chloro-5-fluorobenzeneboronic acid pinacol ester, 96%

Base Information

• Chemical Name: 2-Chloro-5-fluorobenzeneboronic acid pinacol ester, 96%
• CAS No.: 870486-41-2
• Molecular Formula: C12H15BClFO2
• Molecular Weight: 256.512
• Mol file: 870486-41-2.mol

Synonyms:2-CHLORO-5-FLUOROPHENYLBORONIC ACID PINACOL ESTER;2-CHLORO-5-FLUOROBENZENEBORONIC ACID PINACOL ESTER;

Chemical Property of 2-Chloro-5-fluorobenzeneboronic acid pinacol ester, 96%

Chemical Property:

• PSA: 18.46000
• LogP: 2.77830

Purity/Quality:

99%,98%, ^*data from raw suppliers

2-Chloro-5-fluorophenylboronicacidpinacolester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-5-fluorobenzeneboronic acid pinacol ester, 96%

There total 2 articles about 2-Chloro-5-fluorobenzeneboronic acid pinacol ester, 96% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-bromo-1-chloro-4-fluoro-benzene (201849-15-2) + bis(pinacol)diborane (73183-34-3) → 2-(2-Chloro-5-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (870486-41-2)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 18h;

Reference yield:

1-Chloro-4-fluorobenzene (352-33-0) + bis(pinacol)diborane (73183-34-3) → 2-(2-Chloro-5-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (870486-41-2) + 2-(5-chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1190129-77-1)

Guidance literature:

With n-butyllithium; C₂₈H₄₁ClNPPtSi; In hexane; 1,3,5-trimethyl-benzene; at 20 - 150 ℃; for 4h; Overall yield = 91 %; Overall yield = 47 mg; regioselective reaction; Inert atmosphere;

DOI:10.1039/c5cc07263h

upstream raw materials:

2-bromo-1-chloro-4-fluoro-benzene

bis(pinacol)diborane

1-Chloro-4-fluorobenzene