IcoMethasone

Base Information

• Chemical Name: IcoMethasone
• CAS No.: 4647-20-5
• Molecular Formula: C₂₂H₂₉ClO₅
• Molecular Weight: 408.922
• Mol file: 4647-20-5.mol

Synonyms:Icomethasone;Icometasone;Pregna-1,4-diene-3,20-dione,9-chloro-11,17,21-trihydroxy-16-methyl-,(11beta,16alpha);UNII-2LP8SJ795G;

Chemical Property of IcoMethasone

Chemical Property:

• Melting Point: 229-234 °C
• Boiling Point: 600.2±55.0 °C(Predicted)
• PKA: 12.17±0.70(Predicted)
• PSA: 94.83000
• Density: 1.35±0.1 g/cm3(Predicted)
• LogP: 2.16500
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

Icomethasone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Icomethasone is a metabolite of Mometasone Furoate (M490000).

Technology Process of IcoMethasone

There total 3 articles about IcoMethasone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

9β,11β-epoxy-17α,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (981-34-0) → beclomethasone (4419-39-0,4647-20-5)

Guidance literature:

With hydrogenchloride; In dichloromethane; water; at 0 - 25 ℃; for 1.5h; Temperature; Solvent;

DOI:10.1016/j.steroids.2021.108948

Reference yield:

beclomethasone 17,21-dipropionate (5534-09-8) → beclomethasone (4419-39-0,4647-20-5)

Guidance literature:

With potassium hydrogencarbonate; In methanol; at 20 ℃; for 72h;

DOI:10.1021/acs.langmuir.7b01177

Reference yield:

→ beclomethasone (4419-39-0,4647-20-5)

Guidance literature:

upstream raw materials:

beclomethasone 17,21-dipropionate

9β,11β-epoxy-17α,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Downstream raw materials:

C₂₂H₂₇ClO₄

C₂₂H₂₇ClO₄

beclomethasone 17-monopropionate

beclomethasone 17,21-dipropionate

Refernces

• 1、 Hidalgo, Alberto,Salomone, Fabrizio,Fresno, Nieves,Orellana, Guillermo,Cruz, Antonio,Perez-Gil, Jesus. "Efficient Interfacially Driven Vehiculization of Corticosteroids by Pulmonary Surfactant". . p. 7929 - 7939. Retrieved 2017/08/22.
• 2、 -. "Pharmaceutical composition using a mixture of propellant gases for a metered dose inhaler". . . Retrieved 2008/06/13.