Anceron

Base Information Edit

Chemical Name:Anceron
CAS No.:5534-09-8
Molecular Formula:C28H37ClO7
Molecular Weight:521.051
Hs Code.:29372100
NSC Number:755901
DSSTox Substance ID:DTXSID40859913
ChEMBL ID:CHEMBL1319520
Mol file:5534-09-8.mol

Synonyms:Aerobec;AeroBec Forte;Aldecin;Apo-Beclomethasone;Ascocortonyl;Asmabec Clickhaler;Beclamet;Beclazone;Beclazone Easy Breathe;Beclo Asma;Beclo AZU;Beclocort;Becloforte;Beclomet;Beclometasone;Beclomethasone;Beclomethasone Dipropionate;Beclorhinol;Becloturmant;Beclovent;becodisk;Becodisks;Beconase;Beconase AQ;Becotide;Bemedrex Easyhaler;Bronchocort;Dipropionate, Beclomethasone;Ecobec;Filair;Filair Forte;Junik;Nasobec Aqueous;Prolair;Propaderm;Qvar;Respocort;Sanasthmax;Sanasthmyl;Vancenase;Vanceril;Ventolair;Viarin

Suppliers and Price of Anceron

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TCI Chemical
Beclometasone Dipropionate >98.0%(HPLC)
1g
$ 130.00

TCI Chemical
Beclometasone Dipropionate >98.0%(HPLC)
5g
$ 385.00

TRC
BeclomethasoneDipropionate
5g
$ 155.00

TRC
BeclomethasoneDipropionate
500mg
$ 50.00

TCI Chemical
Beclometasone Dipropionate >98.0%(HPLC)
1g
$ 118.00

TCI Chemical
Beclometasone Dipropionate >98.0%(HPLC)
5g
$ 350.00

DC Chemicals
BeclomethasoneDipropionate >98%
1 g
$ 300.00

Crysdot
Beclometasone Dipropionate 98+%
250mg
$ 49.00

Crysdot
Beclometasone Dipropionate 98+%
50mg
$ 35.00

ChemScene
Beclometasone Dipropionate 99.92%
1g
$ 174.00

Total 202 raw suppliers

Chemical Property of Anceron Edit

Chemical Property:

Appearance/Colour:white crystalline powder
Melting Point:117-120 °C
Refractive Index:1.564
Boiling Point:630.5 °C at 760 mmHg
PKA:13.02±0.70(Predicted)
Flash Point:335.1 °C
PSA：106.97000
Density:1.26 g/cm³
LogP:4.08680
Storage Temp.:2-8°C
Solubility.:Chloroform (Slightly), Dioxane (Slightly, Sonicated), Methanol (Slightly, Heated
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:520.2227812
Heavy Atom Count:36
Complexity:1050

Purity/Quality:

99% ^*data from raw suppliers

Beclometasone Dipropionate >98.0%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s): T,Xn
Hazard Codes:T,Xn
Statements: 60-61-36/37/38-20/21/22
Safety Statements: 53-36/37/39-45-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCC(=O)OCC(=O)C1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)Cl)O)C)C)OC(=O)CC
Uses Antiallergic, antiasthmatic (inhalate). Anti-inflammatory (topical) Beclomethasone Dipropionate (Betamethasone Dipropionate EP Impurity E) is an antiallergic, antiasthmatic (inhalate). Anti-inflammatory (topical). antiasthmatic, topical antiinflammatory Anti-arrhythmia Agent, corticosteroids
Biological Functions Beclomethasone dipropionate is used primarily as an inhalation aerosol therapy for asthma and rhinitis. A breakthrough in the discovery of new inhalation corticosteroids with reduced risks from systemic absorption was that the 17α-monopropionate ester of beclomethasone (17-BMP) was more active than BDP and 21-monopropionate (21-BMP) esters. Thus, BDP is a pro-drug that is rapidly metabolized by esterases in the lung and other tissues to its more active metabolite, 17-BMP, which has 30 times greater affinity for the GR than BDP and approximately 14 times dexamethasone (Table 33.5).
Clinical Use Beclomethasone dipropionate is a lipophilic prodrug that, when inhaled, shows a systemic bioavailability of approximately 20% of the administered dose. The 16β-methyl group decreases mineralocorticoid activity, and the 9α-chloro group increases both the glucocorticoid and mineralocorticoid activity, resulting in potent anti-inflammatory activity with little or no salt-retaining effects.

Technology Process of Anceron

There total 8 articles about Anceron which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%