TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE
• CAS No.: 870822-88-1
• Molecular Formula: C16H24N2O4
• Molecular Weight: 308.378
• Hs Code.: 2928000090
• Mol file: 870822-88-1.mol

Synonyms:tert-butyl 2-[1-[4-(ethoxycarbonyl)phenyl]ethyl]hydrazinecarboxylate;

Chemical Property of TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE

Chemical Property:

• PSA: 76.66000
• Density: 1.097g/cm3
• LogP: 3.73540

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl2-(1-(4-(ethoxycarbonyl)phenyl)ethyl)hydrazinecarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE

There total 3 articles about TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl N'-[1-[4-(ethoxycarbonyl)phenyl]ethylidene]hydrazinecarboxylate (870822-87-0) → tert-butyl 2-{1-[4-(ethoxycarbonyl)phenyl]ethyl}hydrazin-1-carboxylate (870822-88-1)

Guidance literature:

With sodium cyanoborohydride; toluene-4-sulfonic acid; In tetrahydrofuran; Inert atmosphere;

DOI:10.1021/jm300579z

Reference yield:

ethyl-4-acetylbenzoate (38430-55-6) → tert-butyl 2-{1-[4-(ethoxycarbonyl)phenyl]ethyl}hydrazin-1-carboxylate (870822-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 80 °C

2: sodium cyanoborohydride; toluene-4-sulfonic acid / tetrahydrofuran / Inert atmosphere

With sodium cyanoborohydride; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;

DOI:10.1021/jm300579z

Reference yield:

4-acetyl-benzoic acid (586-89-0) → tert-butyl 2-{1-[4-(ethoxycarbonyl)phenyl]ethyl}hydrazin-1-carboxylate (870822-88-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 3 h / 80 °C

2: acetic acid / toluene / 80 °C

3: sodium cyanoborohydride; toluene-4-sulfonic acid / tetrahydrofuran / 3 h / 20 °C

With sulfuric acid; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; toluene;

DOI:10.1016/j.bmc.2016.04.053

upstream raw materials:

tert-butyl N'-[1-[4-(ethoxycarbonyl)phenyl]ethylidene]hydrazinecarboxylate

ethyl-4-acetylbenzoate

4-acetyl-benzoic acid

Downstream raw materials:

{1-[4-(ethoxycarbonyl)phenyl]ethyl}hydrazinium chloride

tert-butyl 2-{(1S)-1-[4-(ethoxycarbonyl)phenyl]ethyl}hydrazinecarboxylate

tert-butyl 2-{(1R)-1-[4-(ethoxycarbonyl)phenyl]ethyl}hydrazinecarboxylate

(S)-1-[4-(ethoxycarbonyl)phenyl]ethylhydrazine benzenesulfonate