(S)-4-(1-Hydrazinylethyl)benzoic Acid Ethyl Ester Benzenesulfonate

Base Information

• Chemical Name: (S)-4-(1-Hydrazinylethyl)benzoic Acid Ethyl Ester Benzenesulfonate
• CAS No.: 934495-38-2
• Molecular Formula: C11H16N2O2.C6H6O3S
• Molecular Weight: 366.43
• Mol file: 934495-38-2.mol

Synonyms:(S)-Ethyl 4-(1-hydrazinylethyl)benzoate Benzenesulfonate;(S)-4-(1-Hydrazinylethyl)benzoic Acid Ethyl Ester Benzenesulfonate;4-[(1S)-1-Hydrazinylethyl]benzoic acid ethyl ester benzenesulfonate

Chemical Property of (S)-4-(1-Hydrazinylethyl)benzoic Acid Ethyl Ester Benzenesulfonate

Chemical Property:

Purity/Quality:

98%Min ^*data from raw suppliers

(S)-4-(1-Hydrazinylethyl)benzoicAcidEthylEsterBenzenesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-4-(1-Hydrazinylethyl)benzoic Acid Ethyl Ester Benzenesulfonate is used in the preparation of glucagon receptor antagonists for the treatment of diabetes and related diseases. A benzylhydrazine used in the preparation of glucagon receptor antagonists for the treatment of diabetes and related diseases.

Technology Process of (S)-4-(1-Hydrazinylethyl)benzoic Acid Ethyl Ester Benzenesulfonate

There total 1 articles about (S)-4-(1-Hydrazinylethyl)benzoic Acid Ethyl Ester Benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

tert-butyl 2-{1-[4-(ethoxycarbonyl)phenyl]ethyl}hydrazin-1-carboxylate (870822-88-1) + benzenesulfonic acid (98-11-3) → (S)-1-[4-(ethoxycarbonyl)phenyl]ethylhydrazine benzenesulfonate (934495-38-2)

Guidance literature:

In ethanol; at 60 ℃; optical yield given as %ee; Inert atmosphere; Large scale reaction;

DOI:10.1021/ol902602c

Reference yield:

Ethyl 3-[2-ethoxy-5-(trifluoromethyl)phenyl]-3-oxopropanoate (934495-36-0) + (S)-1-[4-(ethoxycarbonyl)phenyl]ethylhydrazine benzenesulfonate (934495-38-2) + trifluoromethylsulfonic anhydride (358-23-6) → Ethyl 4-[(1S)-1-(3-[2-ethoxy-5-(trifluoromethyl)phenyl]-5-{[(trifluoromethyl)sulfonyl]oxy}-1H-pyrazol-1-yl)ethyl]benzoate (934495-37-1)

Guidance literature:

Ethyl 3-[2-ethoxy-5-(trifluoromethyl)phenyl]-3-oxopropanoate; (S)-1-[4-(ethoxycarbonyl)phenyl]ethylhydrazine benzenesulfonate; In acetonitrile; at 80 ℃; for 10h;

trifluoromethylsulfonic anhydride; With triethylamine; In dichloromethane; at -78 - 20 ℃;

upstream raw materials:

tert-butyl 2-{1-[4-(ethoxycarbonyl)phenyl]ethyl}hydrazin-1-carboxylate

benzenesulfonic acid

Downstream raw materials:

Ethyl 4-[(1S)-1-(3-[2-ethoxy-5-(trifluoromethyl)phenyl]-5-{[(trifluoromethyl)sulfonyl]oxy}-1H-pyrazol-1-yl)ethyl]benzoate