Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-)

Base Information

Chemical Name:Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-)
CAS No.:15207-28-0
Molecular Formula:C₃₀H₄₆N₆O₅
Molecular Weight:570.732
Hs Code.:
Mol file:15207-28-0.mol

Synonyms:CyclosemigramicidinS (8CI); 1H-Pyrrolo[1,2-a][1,4,7,10,13]pentaazacyclopentadecine, cyclic peptidederiv.; Cyclo(L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl)

Suppliers and Price of Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-)

Chemical Property:

PSA：0.00000
LogP:0.00000

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-)

There total 19 articles about Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: (S)-2-[(S)-5-tert-Butoxycarbonylamino-2-((R)-2-{[(S)-1-((R)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyrylamino)-pentanoylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 15207-28-0
cyclo(-D-Phe-Pro-D-Val-Orn-Leu-)

Guidance literature:: (S)-2-[(S)-5-tert-Butoxycarbonylamino-2-((R)-2-{[(S)-1-((R)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyrylamino)-pentanoylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; With trifluoroacetic acid;

With pyridine; In N,N-dimethyl-formamide; at 25 ℃; for 24h;
DOI:10.1246/bcsj.70.899

Reference yield: 38.0%

: (S)-2-[(S)-5-tert-Butoxycarbonylamino-2-((S)-2-{[(S)-1-((R)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyrylamino)-pentanoylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 113-73-5
Gramicidin S

: 15207-28-0
cyclo(D-Phe-Pro-Val-Orn-Leu)

Guidance literature:: (S)-2-[(S)-5-tert-Butoxycarbonylamino-2-((S)-2-{[(S)-1-((R)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyrylamino)-pentanoylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; With trifluoroacetic acid;

With pyridine; In N,N-dimethyl-formamide; at 25 ℃; for 24h;
DOI:10.1246/bcsj.70.899

Reference yield: 35.0%

: 917501-50-9
Boc-D-Phe-Pro-Val-Orn(Boc)-OH

: 113-73-5
Gramicidin S

: 15207-28-0
cyclo(D-Phe-Pro-Val-Orn-Leu)

Guidance literature:: Boc-D-Phe-Pro-Val-Orn(Boc)-OH; H-Leu-oxime resin; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol;

With trifluoroacetic acid; In dichloromethane; for 0.5h;

With acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 25 ℃; for 24h;
DOI:10.1016/j.tetlet.2006.09.146