N-(2-HYDROXYMETHYL-4,5-DIMETHOXY-PHENYL)-4-METHYL-BENZENESULFONAMIDE

Base Information

Chemical Name:N-(2-HYDROXYMETHYL-4,5-DIMETHOXY-PHENYL)-4-METHYL-BENZENESULFONAMIDE
CAS No.:871563-17-6
Molecular Formula:C₁₆H₁₉NO₅S
Molecular Weight:337.397
Hs Code.:
Mol file:871563-17-6.mol

Synonyms:

Suppliers and Price of N-(2-HYDROXYMETHYL-4,5-DIMETHOXY-PHENYL)-4-METHYL-BENZENESULFONAMIDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
N-(2-(Hydroxymethyl)-4,5-dimethoxyphenyl)-4-methylbenzenesulfonamide 97%
1g
$ 643.00

Total 1 raw suppliers

Chemical Property of N-(2-HYDROXYMETHYL-4,5-DIMETHOXY-PHENYL)-4-METHYL-BENZENESULFONAMIDE

Chemical Property:

PSA：93.24000
LogP:3.45910

Purity/Quality:: N-(2-(Hydroxymethyl)-4,5-dimethoxyphenyl)-4-methylbenzenesulfonamide 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(2-HYDROXYMETHYL-4,5-DIMETHOXY-PHENYL)-4-METHYL-BENZENESULFONAMIDE

There total 6 articles about N-(2-HYDROXYMETHYL-4,5-DIMETHOXY-PHENYL)-4-METHYL-BENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 71089-34-4
methyl 4,5-dimethoxy-2-(p-toluenesulfonamido)benzoate

: 871563-17-6
N-(2-hydroxymethyl-4,5-dimethoxyphenyl)-4-methylbenzenesulfonamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;
DOI:10.1002/ejoc.202100021

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 188174-23-4
(2-amino-4,5-dimethoxyphenyl)methanol

: 871563-17-6
N-(2-hydroxymethyl-4,5-dimethoxyphenyl)-4-methylbenzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 12h; Cooling with ice;
DOI:10.1039/c4cc08174a

Reference yield:

: 5653-40-7
2-Amino-4,5-dimethoxybenzoic acid

: 871563-17-6
N-(2-hydroxymethyl-4,5-dimethoxyphenyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 24 h / Reflux

2: pyridine / dichloromethane / 3 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo402132p