Acetic acid, [4-[[3-(aminomethyl)-4-hydroxyphenyl]thio]-2,3-dichlorophenoxy]-, ethyl ester, hydrochloride

Base Information

Chemical Name:Acetic acid, [4-[[3-(aminomethyl)-4-hydroxyphenyl]thio]-2,3-dichlorophenoxy]-, ethyl ester, hydrochloride
CAS No.:87181-33-7
Molecular Formula:C17H17Cl2NO4S.ClH
Molecular Weight:438.759
Hs Code.:

Synonyms:

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Chemical Property of Acetic acid, [4-[[3-(aminomethyl)-4-hydroxyphenyl]thio]-2,3-dichlorophenoxy]-, ethyl ester, hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of Acetic acid, [4-[[3-(aminomethyl)-4-hydroxyphenyl]thio]-2,3-dichlorophenoxy]-, ethyl ester, hydrochloride

There total 11 articles about Acetic acid, [4-[[3-(aminomethyl)-4-hydroxyphenyl]thio]-2,3-dichlorophenoxy]-, ethyl ester, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 87181-33-7
ethyl <2,3-dichloro-4-<<3-(aminomethyl)-4-hydroxyphenyl>sulfenyl>phenoxy>acetate hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: 71 percent / K₂CO₃ / dimethylformamide / Ambient temperature; overnight

2: 95 percent / AlCl₃ / CH₂Cl₂ / Ambient temperature

3: 88 percent / K₂CO₃ / butan-2-one / 2 h / Heating

4: H₂ / 5percent sulfided Pt/C / ethanol

5: 1.) NaNO₂, H₂SO₄, 2.) Na₂SO₄, H₂SO₄ / 1.) H₂O, RT, overnight, 2.) H₂O, reflux, 2 h

6: H₂SO₄ / 2.5 h / Heating

7: H₂SO₄ / acetic acid / Ambient temperature

8: H₂SO₄ / Ambient temperature

9: HCl / ethanol / 4 h / Heating

With hydrogenchloride; aluminium trichloride; sulfuric acid; hydrogen; potassium carbonate; sodium sulfate; sodium nitrite; sulfided Pt/C; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00379a016

Reference yield:

: 87181-26-8
2,3-dichloro-4-ethoxybenzenethiol

: 87181-33-7
ethyl <2,3-dichloro-4-<<3-(aminomethyl)-4-hydroxyphenyl>sulfenyl>phenoxy>acetate hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: 71 percent / K₂CO₃ / dimethylformamide / Ambient temperature; overnight

2: 95 percent / AlCl₃ / CH₂Cl₂ / Ambient temperature

3: 88 percent / K₂CO₃ / butan-2-one / 2 h / Heating

4: H₂ / 5percent sulfided Pt/C / ethanol

5: 1.) NaNO₂, H₂SO₄, 2.) Na₂SO₄, H₂SO₄ / 1.) H₂O, RT, overnight, 2.) H₂O, reflux, 2 h

6: H₂SO₄ / 2.5 h / Heating

7: H₂SO₄ / acetic acid / Ambient temperature

8: H₂SO₄ / Ambient temperature

9: HCl / ethanol / 4 h / Heating

With hydrogenchloride; aluminium trichloride; sulfuric acid; hydrogen; potassium carbonate; sodium sulfate; sodium nitrite; sulfided Pt/C; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00379a016

Reference yield:

: 93135-45-6
2,3-dichloro-4-ethoxybenzenesulfonyl chloride

: 87181-33-7
ethyl <2,3-dichloro-4-<<3-(aminomethyl)-4-hydroxyphenyl>sulfenyl>phenoxy>acetate hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: 87 percent / LiAlH₄ / diethyl ether / 1 h / Heating

2: 71 percent / K₂CO₃ / dimethylformamide / Ambient temperature; overnight

3: 95 percent / AlCl₃ / CH₂Cl₂ / Ambient temperature

4: 88 percent / K₂CO₃ / butan-2-one / 2 h / Heating

5: H₂ / 5percent sulfided Pt/C / ethanol

6: 1.) NaNO₂, H₂SO₄, 2.) Na₂SO₄, H₂SO₄ / 1.) H₂O, RT, overnight, 2.) H₂O, reflux, 2 h

7: H₂SO₄ / 2.5 h / Heating

8: H₂SO₄ / acetic acid / Ambient temperature

9: H₂SO₄ / Ambient temperature

10: HCl / ethanol / 4 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; aluminium trichloride; sulfuric acid; hydrogen; potassium carbonate; sodium sulfate; sodium nitrite; sulfided Pt/C; In diethyl ether; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00379a016