Cytidine, 2'-deoxy-5'-O-[hydroxy(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)phosphin yl]-

Base Information

Chemical Name:Cytidine, 2'-deoxy-5'-O-[hydroxy(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)phosphin yl]-
CAS No.:872003-30-0
Molecular Formula:C14H16N7O7P
Molecular Weight:
Hs Code.:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cytidine, 2'-deoxy-5'-O-[hydroxy(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)phosphin yl]-

Chemical Property:

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Technology Process of Cytidine, 2'-deoxy-5'-O-[hydroxy(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)phosphin yl]-

There total 2 articles about Cytidine, 2'-deoxy-5'-O-[hydroxy(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)phosphin yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 39968-33-7
1-hydroxy-7-aza-benzotriazole

: 1032-65-1,25609-92-1
cytidine 5'-(dihydrogen phosphate)

: 200731-31-3,148893-10-1
HATU

: 872003-30-0
O-(2'-deoxycytidine 5'-O-phosphor-5'-P-yl)-7-azabenzotriazole

Guidance literature:: 1-hydroxy-7-aza-benzotriazole; cytidine 5'-(dihydrogen phosphate); HATU; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With sodium perchlorate; In diethyl ether; N,N-dimethyl-formamide; acetone; at 0 ℃; for 0.333333h;

Reference yield:

: 39968-33-7
1-hydroxy-7-aza-benzotriazole

: 1032-65-1,25609-92-1
cytidine 5'-(dihydrogen phosphate)

: 872003-30-0
O-(2'-deoxycytidine 5'-O-phosphor-5'-P-yl)-7-azabenzotriazole

Guidance literature:: With sodium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In water; at 20 ℃; for 2h; pH=5.0;
DOI:10.1002/anie.200501794