2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate

Base Information

• Chemical Name: 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate
• CAS No.: 200731-31-3
• Molecular Formula: C₁₀H₁₅N₆O*F₆P
• Molecular Weight: 380.233
• DSSTox Substance ID: DTXSID201026946
• Wikidata: Q5628980
• Mol file: 200731-31-3.mol

Synonyms:2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;MFCD00274639;2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate(V);2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate(V);O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl uronium hexafluorophosphate;200731-31-3;O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate (HATU);N,N,N',N'-Tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate;2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyl uronium hexafluorophosphate;O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;N-[(Dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methylmethanaminium hexafluorophosphate;SCHEMBL63612;O-(7-azabenzotriazol-1-yl)-1;JNWBBCNCSMBKNE-UHFFFAOYSA-N;DTXSID201026946;BCP20707;AKOS005762930;AKOS015900573;O-(7-aza-1H-benzotriazole-1-yl)-N;AC-1758;AM83825;SB00011;[dimethylamino(triazolo[4,5-b]pyridin-3-yloxy)methylene]-dimethyl-ammonium hexafluorophosphate;AS-10958;n-[(dimethylamino)-1h-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-n-methylmethanaminium hexafluorophosphate n-oxide;SY002031;FT-0601200;EN300-49821;2-(7-A;Q-201185;Q5628980;3-AMINO-3-(4-TERT-BUTYL-PHENYL)-PROPIONICACID;F0001-0528;o-(7-Azabenzotriazol-1-yl)uronium hexafluoro-phosphate;tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate;(7 azabenzotriazol 1 yl) 1,1,3,3 tetramethyl-uronium hexafluorophosphate;(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;(O-7-azabenzotriazol-1-y)-1,1,3,3-tetramethyluronium hexafluorophosphate;0(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;0-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluroniumhexafluorophosphate;2-(1H-7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphat;2-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;7- azabenzotriazol-1-ylN,N,N',N'-tetramethyluronium hexafluorophosphate;7-azabenzotriazol-1-yl N,N,N',N'-tetramethyluronium hexafluorophosphate;7-azabenzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate;N,N,N',N'-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophospate;N,N,N'N'-Tetramethyl-O-(7-azabenzotriazol-1-yl)uroniumhexafluorophosphate;O-(-7azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;O-(7 azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1- yl)N,N,N',N'-tetramethyluronium hexafluorophosphate;o-(7-azabenzotriazol-1-yl) n,n,n',n'-tetramethyluronium hexafluorophosphate;o-(7-azabenzotriazol-1-yl)-1,1,3,3,-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyl uronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyl-uronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluoro-phosphate;O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophophate;O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluoro-phosphate;O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N' tetramethyluronium hexafluorophosphate;o-(7-azabenzotriazol-1-yl)-N,N,N',N'-te-tramethyluroniumhexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl-uroniumhexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophophate;O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphat;o-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluorphosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexaflurophosphate;O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM PF6;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluroniumhexafluoro-phosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluroniumhexafluorophosphate;o-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluroniumhexaflurophosphate;O-(7-azabenzotriazol-1-yl)1,1,3,3-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)N,N,N',N'-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;O-(7-Azabenzotriazol1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluroniumhexafluorophosphate;O-(7-azabenzotriazole-1yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;O-(7-azabenztriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;o-(7azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluorophosphate;0-(7-Azabenzotriazol-1-yl)-N,N, N',N'-tetramethyluronium hexafluorophosphate;0-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;0-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluroniunn hexafluorophosphate;0-(7-azabenzotriazol-1-yl-)-N,N,N',N'-tetramethyluronium hexafluorophosphate;2-(1H-7-azabenzotriazol-1-yl) -1,1,3,3-tetramethyl uronium hexafluorophosphate;2-(1H-7-Azabenzotriazol-1-yl)--1,1,3,3-tetramethyluronium hexafluorophosphate;2-(1H-7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyl uronium hexafluorophosphate;2-(1H-7-Azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;2-(7 -aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;2-(7 aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;2-(7-Aza-1H-benzo-triazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetramethyl uronium hexafluorophosphate;2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexa-fluorophosphate;2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;2-(7-Aza-1H-Benzotriazole -1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetra-methyluronium hexafluorophosphate;2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyl-uronium hexafluorophosphate;2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluoro-phosphate;2-(7-aza-1h-benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate;2-(7-Aza-1H-benzotriazole-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;2-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;bis(dimethylamino)methylene-(triazolo[5,4-b]pyridin-3-yl)oxonium hexafluorophosphate;n,n,n',n',-tetramethyl-o-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate;N,N,N',N'-tetramethyl-O-(7-azabenzotriazol-1-yl)-uronium hexafluorophosphate;O-(1H-7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;O-(7- Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;O-(7-aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluroniumhexafluoro phosphate;O-(7-Azabenzotriazol-1-yl) -N,N,N',N'-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-1N,N,N',N'-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N, N, N', N',-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N, N, N', N'-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N, N,N',N'-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N, N', N'-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N, N',N'-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N,N', N'-tetramethyl uronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N,N', N'-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N',-tetramethyluronium hexafluorophosphat;o-(7-azabenzotriazol-1-yl)-n,n,n',n',-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N',-tetramethyluronium hexafluorphosphate;o-(7-azabenzotriazol-1-yl)-n,n,n',n',-tetramethyluroniumhexafluoro-phosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetra-methyluronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl-uronium hexafluoro-phosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl-uronium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl-uroniumhexafluoro-phosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethylur onium hexafluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hex afluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexa-fluorophosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluoro phosphate;O-(7-Azabenzotriazol-1-Yl)-N,N,N',N'-tetramethyluronium hexafluoro-phosphate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphorate;O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetrarnethyluronium hexafluorophosphate;O-(7-Azabenzotriazol-1-yl)-N,N,N`,N`-tetramethyluronium Hexafluorophosphate (HATU);O-(7-azabenzotriazole-1-yl)-N,N,N',N',-tetramethyluronium hexafluorophosphate;O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;(dimethylamino)-N,N-dimethyl(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy) methan iminium hexafluorophosphate;(dimethylamino)-N,N-dimethyl(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methaniminium hexafluorophosphate;[(dimethylamino)({3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy})methylidene]dimethylazanium;hexafluoro-lambda5-phosphanuide;[dimethylamino(triazolo[4,5-b]pyridin-3-yloxy)methylidene]-dimethylazanium,hexafluorophosphate;[dimethylamino-([1,2,3]triazolo[4,5-b]pyridin-3-yloxy)-methylene]-dimethyl-ammonium hexafluoro phosphate;[Dimethylamino-([1,2,3]triazolo[4,5-b]pyridin-3-yloxy)-methylene]-dimethyl-ammonium hexafluorophosphate;[Dimethylamino-([1,2,3]triazolo[4,5-b]pyridin-3-yloxy)-methylene]dimethylammonium hexafluorophosphate;[dimethylamino-(1,2,3-triazolo[4,5-b]pyrid-3-yloxy)methylene]dimethylammonium hexafluorophosphate;2-(3H-[1,2,3]triazolo [4,5-b]pyridin-3-yl)-1,1,3 ,3-tetramethylisouronium hexafluorophosphate(V);2-(3H-[1,2,3]triazolo [4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate (V);2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethyl isouronium hexafluorophosphate(V);2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluoro-phosphate(V);2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate (V);Methanaminium, N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) (1:1);N-[(dimethyl-amino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylidene]-N-methylmethanaminium hexafluorophosphate;N-[(dimethylamino) (3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methylmethanaminium hexafluorophosphate;N-[(dimethylamino) (3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylidene]-N-methylmethanaminium hexafluorophosphate;N-[(dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)-methylidene]-N-methylmethanaminium hexafluorophosphate;N-[(Dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-methanaminium hexafluorophosphate;N-[(dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylidene]-N-methyl-methanaminium hexafluorophosphate;N-[(dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylidene]-N-methylmethanaminium hexafluorophosphate;n-[(dimethylamino)(3h[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylidene]-n-methylmethanaminium hexafluorophosphate;N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminiumhexafluorophosphate N-oxide;O-(7-Azabenzotriazol-1-yl)-N,N,N inverted exclamation mark ,N inverted exclamation mark -tetramethyluronium Hexafluorophosphate (HATU)

Chemical Property of 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 3
• Exact Mass: 380.09491509
• Heavy Atom Count: 24
• Complexity: 351

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(C)C(=[N+](C)C)ON1C2=C(C=CC=N2)N=N1.F[P-](F)(F)(F)(F)F

Technology Process of 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate

There total 1 articles about 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ tetrabutylammonium salt + HATU (200731-31-3,148893-10-1)

Guidance literature:

Reference yield: 91.0%

(1R,2S,5R)-5-((tert-butyldiphenylsilyl)oxy)-2-(methoxycarbonyl)-2-methylcyclohexane-1-carboxylic acid + HATU (200731-31-3,148893-10-1) → 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl) 1-methyl (1S,2R,4R)-4-((tert-butyldiphenylsilyl)oxy)-1-methylcyclohexane-1,2-dicarboxylate

Guidance literature:

(1R,2S,5R)-5-((tert-butyldiphenylsilyl)oxy)-2-(methoxycarbonyl)-2-methylcyclohexane-1-carboxylic acid; HATU; In N,N-dimethyl-formamide; at 18 - 27 ℃; for 0.0833333h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h;

Reference yield: 91.0%

5-(S)-azidomethyl-3-[4'-carboxy-3'-fluorophenyl-)oxazolidine-2-one + 3-methyl-N-(3-methylbutyl)-1-butanamine (544-00-3) + HATU (200731-31-3,148893-10-1) → 5-(S)-azidomethyl-3-[4'-aminocarbonyl-3'-fluorophenyl]oxazolidine-2-one

Guidance literature:

With ammonium chloride; In ethyl acetate; N,N-dimethyl-formamide;

Downstream raw materials:

Z-Aib-OAt

O-(2'-deoxycytidine 5'-O-phosphor-5'-P-yl)-7-azabenzotriazole

1-hydroxy-7-aza-benzotriazole

tris[4-(β-benzyloxycarbonylaminomethyl-N-t-butoxycarbonyl-L-alanyl)aminophenyl]methane

Refernces

Synthesis and Evaluation of Dolastatin 10 Analogues Containing Heteroatoms on the Amino Acid Side Chains

10.1021/acs.jnatprod.7b00359

The research focuses on the synthesis and evaluation of dolastatin 10 analogues, which are of significant interest in cancer research due to their potent in vitro activity and potential use as payloads in antibody drug conjugates (ADCs). The study aims to modify the P2 subunit of the dolastatin 10 core scaffold by introducing heteroatoms to the P2 side chain, resulting in compounds that maintain potent in vitro activity. The most active compounds were found to contain azides in the P2 unit and required a phenylalanine-derived P5 subunit. The researchers synthesized a series of auristatins, which are derivatives of dolastatin 10, using various amino acids and chemical modifications, including amines, azides, oxygens, and thiols. Key chemicals used in the synthesis process included Fmoc-protected amino acids, CMPI (2-chloro-1-methylpyridinium iodide), HATU (1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate), TFA (trifluoroacetic acid), and other reagents for specific coupling and deprotection steps. The conclusions of the research indicated that the P2 side chain modifications could be active in vitro, but these modified compounds followed a different activity trend than valine-based P2 compounds, and the presence of an ester or amide at the P5 position was crucial for the activity of these molecules in vitro.