1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene

Base Information

• Chemical Name: 1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene
• CAS No.: 24124-59-2
• Molecular Formula: C15H16 O6 S2
• Molecular Weight: 356.42
• Hs Code.: 2904100000
• Mol file: 24124-59-2.mol

Synonyms:Methanediol,bis(4-methylbenzenesulfonate) (9CI); Methanediol, di-p-toluenesulfonate (8CI);NSC 318486

Chemical Property of 1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene

Chemical Property:

• Vapor Pressure: 1.61E-10mmHg at 25°C
• Melting Point: 116-118°C
• Boiling Point: 523.2°Cat760mmHg
• Flash Point: 270.2°C
• PSA: 103.50000
• Density: 1.356g/cm³
• LogP: 4.53330
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methylenebis(Toluene-4-sulfonate) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene

There total 6 articles about 1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

diiodomethane (75-11-6) + silver(I) 4-methylbenzenesulfonate (16836-95-6) → methylene ditosylate (24124-59-2)

Guidance literature:

In acetonitrile; at 60 ℃; for 24h;

DOI:10.1002/cmdc.201300522

Reference yield: 87.0%

silver(I) 4-methylbenzenesulfonate (16836-95-6) + methyl iodide (74-88-4) → methylene ditosylate (24124-59-2)

Guidance literature:

In acetonitrile; for 24h; Reflux;

DOI:10.1002/cmdc.201500420

Reference yield: 53.0%

→ methylene ditosylate (24124-59-2)

Guidance literature:

upstream raw materials:

diiodomethane

silver(I) 4-methylbenzenesulfonate

Chloroiodomethane

methyl p-toluene sulfonate

Downstream raw materials:

4,6-ditosylperhydro-1,4,6-oxadiazonine

naphthalene

1H-Cyclobutanaphthalene

chloromethyl tosylate

Refernces

Improved synthesis of [¹⁸F]fluoromethyl tosylate, a convenient reagent for radiofluoromethylations

10.1002/jlcr.949

The research presents an improved synthesis method for [18F]fluoromethyl tosylate, a reagent crucial for radiofluoromethylation processes. The study reexamined the preparation of this compound through the reaction of bis(tosyloxy)methane with 18F-, which was reported to yield [18F]fluoromethyl tosylate along with [18F]tosyl fluoride. The experiments involved various reaction conditions, including the addition of water, to optimize the yield of [18F]fluoromethyl tosylate, which was significantly increased to 71±6% with the defined reaction conditions. The analyses used in the study included thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC) to monitor the product formation and purity. The synthesized [18F]fluoromethyl tosylate was then used to produce [18F]fluticasone propionate and other radiolabeled compounds, demonstrating its utility as a labeling reagent.