5-Hydroxy-3-[(4-hydroxyphenyl)methylene]benzofuran-2(3H)-one

Base Information

• Chemical Name: 5-Hydroxy-3-[(4-hydroxyphenyl)methylene]benzofuran-2(3H)-one
• CAS No.: 27439-06-1
• Molecular Formula: C₁₅H₁₀O₄
• Molecular Weight: 254.242
• Mol file: 27439-06-1.mol

Synonyms:2(3H)-Benzofuranone,5-hydroxy-3-(p-hydroxybenzylidene)- (8CI); 2(3H)-Benzofuranone, 5-hydroxy-3-[(4-hydroxyphenyl)methylene]-,(E)-; Marginalin

Chemical Property of 5-Hydroxy-3-[(4-hydroxyphenyl)methylene]benzofuran-2(3H)-one

Chemical Property:

• PSA: 66.76000
• LogP: 2.55740

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Hydroxy-3-[(4-hydroxyphenyl)methylene]benzofuran-2(3H)-one

There total 5 articles about 5-Hydroxy-3-[(4-hydroxyphenyl)methylene]benzofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Hydroxy-2-coumaranone (2688-48-4) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 5-hydroxy-3-[(4-hydroxyphenyl)methylidene]-benzo[b]furan-2-one (27439-06-1)

Guidance literature:

With toluene-4-sulfonic acid; In xylene; at 140 ℃;

DOI:10.1016/j.bmcl.2005.02.052

Reference yield:

5-Hydroxy-2-coumaranone (2688-48-4) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 5-hydroxy-3-[(4-hydroxyphenyl)methylidene]-benzo[b]furan-2-one (27439-06-1) + (Z)-5-hydroxy-3-<(4-hydroxyphenyl)methylene>-2(3H)-benzofuranone (107680-50-2)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 15h; pH=8; Title compound not separated from byproducts;

DOI:10.1016/j.tet.2006.08.048

Reference yield:

5-Hydroxy-2-coumaranone (2688-48-4) + 4-(tetrahydropyran-2-yloxy)benzaldehyde (74189-56-3) → 5-hydroxy-3-[(4-hydroxyphenyl)methylidene]-benzo[b]furan-2-one (27439-06-1) + (Z)-5-hydroxy-3-<(4-hydroxyphenyl)methylene>-2(3H)-benzofuranone (107680-50-2)

Guidance literature:

5-Hydroxy-2-coumaranone; 4-(tetrahydropyran-2-yloxy)benzaldehyde; With potassium hydroxide; In ethanol; at 20 ℃; for 12h;

With hydrogenchloride; water; In ethanol; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2010.03.023

upstream raw materials:

5-Hydroxy-2-coumaranone

4-hydroxy-benzaldehyde

1-(2-hydroxy-5-methoxyphenyl)ethan-1-one

5-methoxybenzofuran-2(3H)-one

Downstream raw materials:

5-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-3H-benzofuran-2-one; compound with N¹-(3-amino-propyl)-butane-1,4-diamine

5-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-3H-benzofuran-2-one; compound with N,N'-bis-(3-amino-propyl)-butane-1,4-diamine

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