2688-48-4Relevant articles and documents
An Efficient Synthesis of Homogentisic Acid
Bloomer, James L.,Damodaran, Kalyani M.
, p. 111 (1980)
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Total synthesis of clavatadine A
Conn, Stephanie J.,Vreeland, Shannon M.,Wexler, Alexandra N.,Pouwer, Rebecca N.,Quinn, Ronald J.,Chamberland, Stephen
, p. 120 - 124 (2015)
The first total synthesis of the potent and selective human blood coagulation factor XIa inhibitor clavatadine A (1) is described. Direct, early-stage guanidinylation enabled rapid, convergent access to an immediate clavatadine A precursor. Concomitant lactone hydrolysis and guanidine deprotection with aqueous acid cleanly provided clavatadine A (1) in only four steps (longest linear sequence, 41-43% overall yield).
Lewis acid promoted synthesis of 2(3H)-benzofuranones
Babu, B. Ravindra,Bali, Shilpika,Sakhuja, Rajeev,Jain, Subhash C.
, p. 2546 - 2548 (2007/10/03)
A Lewis acid promoted one-step synthesis of 2(3H)-benzofuranones via an intramolecular rearrangement of the corresponding substituted O-methoxyacetylbenzenes and coumarins is described.
Ketene S,N-Acetals as Synthetic Intermediates for Heterocycles. Reaction of Ketene S,N-Acetals with 1,4-Quinones
Takahata, Hiroki,Anazawa, Akira,Moriyama, Keiko,Yamazaki, Takao
, p. 1501 - 1504 (2007/10/02)
Annelation of ketene S,N-acetals with 1,4-quinones is found to give benzo- and naphthofurans bearing enamine groups.Subsequent enamine reaction allows the formation of 1-benz- and naphthooxepines and benzofuran-2-ones.