Pyrazolo[1,5-d][1,2,4]triazin-2-ol, 3-(1,1-dimethylethyl)-7-[5-(hydroxymethyl)-3-isoxazolyl]-, 4-methylbenzenesulfonate (ester)

Base Information

• Chemical Name: Pyrazolo[1,5-d][1,2,4]triazin-2-ol, 3-(1,1-dimethylethyl)-7-[5-(hydroxymethyl)-3-isoxazolyl]-, 4-methylbenzenesulfonate (ester)
• CAS No.: 875489-11-5
• Molecular Formula: C₂₀H₂₁N₅O₅S
• Molecular Weight: 443.483
• Mol file: 875489-11-5.mol

Synonyms:

Chemical Property of Pyrazolo[1,5-d][1,2,4]triazin-2-ol, 3-(1,1-dimethylethyl)-7-[5-(hydroxymethyl)-3-isoxazolyl]-, 4-methylbenzenesulfonate (ester)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrazolo[1,5-d][1,2,4]triazin-2-ol, 3-(1,1-dimethylethyl)-7-[5-(hydroxymethyl)-3-isoxazolyl]-, 4-methylbenzenesulfonate (ester)

There total 2 articles about Pyrazolo[1,5-d][1,2,4]triazin-2-ol, 3-(1,1-dimethylethyl)-7-[5-(hydroxymethyl)-3-isoxazolyl]-, 4-methylbenzenesulfonate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

5-(hydroxymethyl)-1,2-oxazole-3-carbohydrazide (875489-09-1) + 4-tert-Butyl-5-formyl-3-[(4-methylphenyl)sulphonyloxy]pyrazole (265643-79-6) → toluene-4-sulfonic acid 3-tert-butyl-7-(5-hydroxymethyl-isoxazol-3-yl)-pyrazolo[1,5-d][1,2,4]triazin-2-yl ester (875489-11-5)

Guidance literature:

5-(hydroxymethyl)-1,2-oxazole-3-carbohydrazide; 4-tert-Butyl-5-formyl-3-[(4-methylphenyl)sulphonyloxy]pyrazole; In xylene; Heating;

at 200 ℃;

DOI:10.1016/j.bmcl.2005.11.012

Reference yield:

ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate (123770-62-7) → toluene-4-sulfonic acid 3-tert-butyl-7-(5-hydroxymethyl-isoxazol-3-yl)-pyrazolo[1,5-d][1,2,4]triazin-2-yl ester (875489-11-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 90 percent / NH₂NH₂*H₂O

2.1: xylene / Heating

2.2: 22 percent / 200 °C

With hydrazine hydrate; In xylene;

DOI:10.1016/j.bmcl.2005.11.012

upstream raw materials:

5-(hydroxymethyl)-1,2-oxazole-3-carbohydrazide

4-tert-Butyl-5-formyl-3-[(4-methylphenyl)sulphonyloxy]pyrazole

ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate