1(2H)-Pyridinecarboxylic acid, 2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,4-dihydro-6-[[(trifluoro methyl)sulfonyl]oxy]-, phenylmethyl ester, (2S)-

Base Information

Chemical Name:1(2H)-Pyridinecarboxylic acid, 2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,4-dihydro-6-[[(trifluoro methyl)sulfonyl]oxy]-, phenylmethyl ester, (2S)-
CAS No.:875584-44-4
Molecular Formula:C31H34F3NO6SSi
Molecular Weight:633.761
Hs Code.:

1(2H)-Pyridinecarboxylic acid,
2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,4-dihydro-6-[[(trifluoro
methyl)sulfonyl]oxy]-, phenylmethyl ester, (2S)-

Synonyms:

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Chemical Property of 1(2H)-Pyridinecarboxylic acid, 2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,4-dihydro-6-[[(trifluoro methyl)sulfonyl]oxy]-, phenylmethyl ester, (2S)-

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Technology Process of 1(2H)-Pyridinecarboxylic acid, 2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,4-dihydro-6-[[(trifluoro methyl)sulfonyl]oxy]-, phenylmethyl ester, (2S)-

There total 5 articles about 1(2H)-Pyridinecarboxylic acid, 2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,4-dihydro-6-[[(trifluoro methyl)sulfonyl]oxy]-, phenylmethyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: phenylmethyl 2-(tert-butyldiphenylsilyloxymethyl)-6-oxopiperidine-1-carboxylate

: 145100-51-2
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide

: 875584-44-4
phenylmethyl 2-(tert-butyldiphenylsilyloxymethyl)-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylate

Guidance literature:: phenylmethyl 2-(tert-butyldiphenylsilyloxymethyl)-6-oxopiperidine-1-carboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide; In tetrahydrofuran; hexane; for 0.5h; Inert atmosphere; Cooling;
DOI:10.3184/174751917X14858862342223

Reference yield: 91.0%

: 875584-43-3
2-(tert-butyl-diphenyl-silanyloxymethyl)-6-oxo-piperidine-1-carboxylic acid benzyl ester

: 145100-51-2
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide

: 875584-44-4
phenylmethyl 2-(tert-butyldiphenylsilyloxymethyl)-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -40 ℃;
DOI:10.1016/j.tetlet.2005.11.047

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 875584-44-4
phenylmethyl 2-(tert-butyldiphenylsilyloxymethyl)-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / BuLi / tetrahydrofuran / -78 - 0 °C

2: 91 percent / LiHMDS / tetrahydrofuran / -78 - -40 °C

With n-butyllithium; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2005.11.047