1-Piperidinecarboxylic acid, 6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3-ethenyl-2-(hydroxymeth yl)-, phenylmethyl ester, (2R,3S,6S)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3-ethenyl-2-(hydroxymeth yl)-, phenylmethyl ester, (2R,3S,6S)-
CAS No.:875587-39-6
Molecular Formula:C33H41NO4Si
Molecular Weight:543.778
Hs Code.:

1-Piperidinecarboxylic acid,
6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3-ethenyl-2-(hydroxymeth
yl)-, phenylmethyl ester, (2R,3S,6S)-

Synonyms:

Suppliers and Price of 1-Piperidinecarboxylic acid, 6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3-ethenyl-2-(hydroxymeth yl)-, phenylmethyl ester, (2R,3S,6S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3-ethenyl-2-(hydroxymeth yl)-, phenylmethyl ester, (2R,3S,6S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3-ethenyl-2-(hydroxymeth yl)-, phenylmethyl ester, (2R,3S,6S)-

There total 6 articles about 1-Piperidinecarboxylic acid, 6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3-ethenyl-2-(hydroxymeth yl)-, phenylmethyl ester, (2R,3S,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 875587-38-5
1-phenylmethyl 2-methyl 6-(tert-butyldiphenylsilyloxymethyl)-3-vinylpiperidine-1,2-dicarboxylate

: 875587-39-6
phenylmethyl 6-(tert-butyldiphenylsilyloxymethyl)-2-hydroxymethyl-3-vinylpiperidine-1-carboxylate

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/j.tetlet.2005.11.046

Reference yield:

: 875584-45-5
1-phenylmethyl 2-methyl 6-(tert-butyldiphenylsilyloxymethyl)-5,6-dihydro-4H-pyridine-1,2-dicarboxylate

: 875587-39-6
phenylmethyl 6-(tert-butyldiphenylsilyloxymethyl)-2-hydroxymethyl-3-vinylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / diethyl ether / -78 - -10 °C

2: 92 percent / lithium triethylborohydride / tetrahydrofuran / 0 °C

With lithium triethylborohydride; In tetrahydrofuran; diethyl ether;
DOI:10.1016/j.tetlet.2005.11.046

Reference yield:

: 875584-44-4
phenylmethyl 2-(tert-butyldiphenylsilyloxymethyl)-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylate

: 875587-39-6
phenylmethyl 6-(tert-butyldiphenylsilyloxymethyl)-2-hydroxymethyl-3-vinylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 15 h / 75 °C

2.1: diethyl ether / 1 h / -78 - -10 °C / Inert atmosphere

3.1: lithium triethylborohydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium triethylborohydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 2.1: |Michael Addition;
DOI:10.3184/174751917X14858862342223