Benzamide, 4-[(3-aminophenyl)[4-[(4-fluorophenyl)methyl]-1-piperazinyl]methyl]-N,N- diethyl-

Base Information

Chemical Name:Benzamide, 4-[(3-aminophenyl)[4-[(4-fluorophenyl)methyl]-1-piperazinyl]methyl]-N,N- diethyl-
CAS No.:875647-78-2
Molecular Formula:C29H35FN4O
Molecular Weight:474.622
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzamide, 4-[(3-aminophenyl)[4-[(4-fluorophenyl)methyl]-1-piperazinyl]methyl]-N,N- diethyl-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzamide, 4-[(3-aminophenyl)[4-[(4-fluorophenyl)methyl]-1-piperazinyl]methyl]-N,N- diethyl-

There total 4 articles about Benzamide, 4-[(3-aminophenyl)[4-[(4-fluorophenyl)methyl]-1-piperazinyl]methyl]-N,N- diethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1309859-03-7
N,N-diethyl-4-[[4-(4-fluorobenzyl)piperazin-1-yl](3-nitrophenyl)methyl]benzamide

: 875647-78-2
4-{(3-aminophenyl)[4-(4-fluorobenzyl)piperazin-1-yl]methyl}-N,N-diethylbenzamide

Guidance literature:: With hydrogen; platinum on carbon; In water; isopropyl alcohol; at 40 ℃; for 6h;

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 875647-78-2
4-{(3-aminophenyl)[4-(4-fluorobenzyl)piperazin-1-yl]methyl}-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: butyl magnesium bromide; n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -10 - -5 °C / Inert atmosphere

1.2: -40 - -20 °C

2.1: thionyl chloride / acetic acid butyl ester / 1.5 h / 35 - 45 °C

3.1: potassium carbonate; potassium iodide / butanone / 23 h / Reflux

4.1: hydrogen / platinum on carbon / isopropyl alcohol; water / 6 h / 40 °C

With n-butyllithium; thionyl chloride; hydrogen; butyl magnesium bromide; potassium carbonate; potassium iodide; platinum on carbon; In tetrahydrofuran; hexane; acetic acid butyl ester; water; isopropyl alcohol; butanone;

Reference yield:

: 1711-02-0
4-iodobenzoic acid chloride

: 875647-78-2
4-{(3-aminophenyl)[4-(4-fluorobenzyl)piperazin-1-yl]methyl}-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / -78 - -65 °C / Inert atmosphere

2.2: 0.5 h / -78 °C

3.1: thionyl chloride / acetic acid butyl ester / 1.5 h / 35 - 45 °C

4.1: potassium carbonate; potassium iodide / butanone / 23 h / Reflux

5.1: hydrogen / platinum on carbon / isopropyl alcohol; water / 6 h / 40 °C

With n-butyllithium; thionyl chloride; hydrogen; potassium carbonate; triethylamine; potassium iodide; platinum on carbon; In tetrahydrofuran; hexane; dichloromethane; acetic acid butyl ester; water; isopropyl alcohol; butanone;