N,N-diethyl-4-[[4-(4-fluorobenzyl)piperazin-1-yl](3-nitrophenyl)methyl]benzamide

Base Information

Chemical Name:N,N-diethyl-4-[[4-(4-fluorobenzyl)piperazin-1-yl](3-nitrophenyl)methyl]benzamide
CAS No.:1309859-03-7
Molecular Formula:C₂₉H₃₃FN₄O₃
Molecular Weight:504.604
Hs Code.:

Synonyms:N,N-diethyl-4-[[4-(4-fluorobenzyl)piperazin-1-yl](3-nitrophenyl)methyl]benzamide

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Chemical Property of N,N-diethyl-4-[[4-(4-fluorobenzyl)piperazin-1-yl](3-nitrophenyl)methyl]benzamide

Chemical Property:

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Technology Process of N,N-diethyl-4-[[4-(4-fluorobenzyl)piperazin-1-yl](3-nitrophenyl)methyl]benzamide

There total 6 articles about N,N-diethyl-4-[[4-(4-fluorobenzyl)piperazin-1-yl](3-nitrophenyl)methyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1309859-02-6
4-[chloro(3-nitrophenyl)methyl]-N,N-diethylbenzamide

: 70931-28-1
1-(4-fluorophenylmethyl)piperazine

: 1309859-03-7
N,N-diethyl-4-[[4-(4-fluorobenzyl)piperazin-1-yl](3-nitrophenyl)methyl]benzamide

Guidance literature:: With potassium carbonate; potassium iodide; In butanone; for 23h; Reflux;

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 1309859-03-7
N,N-diethyl-4-[[4-(4-fluorobenzyl)piperazin-1-yl](3-nitrophenyl)methyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: butyl magnesium bromide; n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -10 - -5 °C / Inert atmosphere

1.2: -40 - -20 °C

2.1: thionyl chloride / acetic acid butyl ester / 1.5 h / 35 - 45 °C

3.1: potassium carbonate; potassium iodide / butanone / 23 h / Reflux

With n-butyllithium; thionyl chloride; butyl magnesium bromide; potassium carbonate; potassium iodide; In tetrahydrofuran; hexane; acetic acid butyl ester; butanone;

Reference yield:

: 1711-02-0
4-iodobenzoic acid chloride

: 1309859-03-7
N,N-diethyl-4-[[4-(4-fluorobenzyl)piperazin-1-yl](3-nitrophenyl)methyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / -78 - -65 °C / Inert atmosphere

2.2: 0.5 h / -78 °C

3.1: thionyl chloride / acetic acid butyl ester / 1.5 h / 35 - 45 °C

4.1: potassium carbonate; potassium iodide / butanone / 23 h / Reflux

With n-butyllithium; thionyl chloride; potassium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; hexane; dichloromethane; acetic acid butyl ester; butanone;