(1R,2R)-cyclohexane-1,2-diamine;dichloroplatinum

Base Information

• Chemical Name: (1R,2R)-cyclohexane-1,2-diamine;dichloroplatinum
• CAS No.: 61848-66-6
• Molecular Formula: C6H14Cl2N2Pt
• Molecular Weight: 380.177
• Hs Code.: 2843900000
• Mol file: 61848-66-6.mol

Synonyms:SCHEMBL1155599;LS-117661

Chemical Property of (1R,2R)-cyclohexane-1,2-diamine;dichloroplatinum

Chemical Property:

• Melting Point: >256°C (dec.)
• Boiling Point: 193.6°Cat760mmHg
• Flash Point: 75°C
• PSA: 24.06000
• Density: g/cm³
• LogP: 2.43950
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 379.018198
• Heavy Atom Count: 11
• Complexity: 65.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N’)Dichloridoplatinum(II) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C(C1)N)N.Cl[Pt]Cl
• Isomeric SMILES: C1CC[C@H]([C@@H](C1)N)N.Cl[Pt]Cl
• Uses: [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N’) dichloridoplatinum(II) is an impurity of Oxiplatin (O845075), third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.

Technology Process of (1R,2R)-cyclohexane-1,2-diamine;dichloroplatinum

There total 16 articles about (1R,2R)-cyclohexane-1,2-diamine;dichloroplatinum which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

potassium tetrachloroplatinate + (1R,2R)-1,2-diaminocyclohexane (20439-47-8) → {(1R,2R)-cyclohexane-1,2-diamine}dichloridoplatinum(II) (38780-40-4,52691-24-4,61848-70-2,61848-66-6,61848-62-2)

Guidance literature:

In water; at 35 ℃; for 25h; Temperature; Microwave irradiation;

Reference yield: 96.0%

potassium tetrachloroplatinate(II) (10025-99-7) + (1R,2R)-1,2-diaminocyclohexane (20439-47-8) → {(1R,2R)-cyclohexane-1,2-diamine}dichloridoplatinum(II) (38780-40-4,52691-24-4,61848-70-2,61848-66-6,61848-62-2)

Guidance literature:

In water; for 4h;

DOI:10.1016/j.ica.2017.05.067

Reference yield: 82.0%

potassium tetrachloroplatinate(II) (10025-99-7) + rac-diaminocyclohexane (694-83-7) → {(1R,2R)-cyclohexane-1,2-diamine}dichloridoplatinum(II) (38780-40-4,52691-24-4,61848-70-2,61848-66-6,61848-62-2)

Guidance literature:

In hydrogenchloride; reaction mixture was held at 55°C for 72 h, then at 7°C for 10 h in absence of light and oxygen;; filtered, washed with water, dried under vacuum;;

DOI:10.1016/S0020-1693(00)81554-6

upstream raw materials:

{Pt(trans-(R,R-1,2-diaminocyclohexane))(ascorbato-C⁽²⁾,O⁽⁵⁾)}methanesulfonate

chloride

{PtCl(diphenyl sulfoxide)(R,R-1,2-diaminocyclohexane)}NO₃

{PtCl(dimethyl sulfoxide) (R,R-1,2-diaminocyclohexane)}NO₃

Downstream raw materials:

{Pt(R,R-DACH)SO₄}*H₂O

(dach)Pt(SO₄)

{PtCl(S,(-)-MeTolSO)(R,R-1,2-diaminocyclohexane)}NO₃

Pd[Ph₂P(O)NP(S)Ph₂-S]2(1,2-diaminocyclohexane)

Refernces

• 1、 Barbanente, Alessandra,Intini, Francesco P.,Margiotta, Nicola,Natile, Giovanni,Pacifico, Concetta. "One-Pot Synthesis of New Organometallic Compounds with Platinum-Carbon Bond". . . Retrieved 2020/02/04.
• 2、 Konovalov, Bata,?ivkovi?, Marija D.,Milovanovi?, Jelena Z.,Djordjevi?, Dragana B.,Arsenijevi?, Aleksandar N.,Vasi?, Ivana R.,Janji?, Goran V.,Franich, Andjela,Manojlovi?, Dragan,Skrivanj, Sandra,Milovanovi?, Marija Z.,Djuran, Milo? I.,Rajkovi?, Sne?ana. "Synthesis, cytotoxic activity and DNA interaction studies of new dinuclear platinum(ii) complexes with an aromatic 1,5-naphthyridine bridging ligand: DNA binding mode of polynuclear platinum(ii) complexes in relation to the complex structure". . p. 15091 - 15102. Retrieved 2018/11/10.