2-(4-phenylbutyl)pyridine

Base Information

• Chemical Name: 2-(4-phenylbutyl)pyridine
• CAS No.: 5520-22-9
• Molecular Formula: C15H17 N
• Molecular Weight: 211.307
• Hs Code.: 2933399090
• Mol file: 5520-22-9.mol

Synonyms:NSC 14709

Chemical Property of 2-(4-phenylbutyl)pyridine

Chemical Property:

• Vapor Pressure: 0.000456mmHg at 25°C
• Boiling Point: 324.7°Cat760mmHg
• Flash Point: 136.3°C
• PSA: 12.89000
• Density: 1.01g/cm³
• LogP: 3.64700

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-phenylbutyl)pyridine

There total 10 articles about 2-(4-phenylbutyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(3-butenyl)pyridine (2294-75-9) + phenylboronic acid (98-80-6) → 2-(4-phenylbutyl)pyridine (5520-22-9)

Guidance literature:

With bromopentacarbonylmanganese(I); potassium tert-butylate; In tetrahydrofuran; at 120 ℃; for 12h; regioselective reaction; Schlenk technique; Inert atmosphere; Molecular sieve;

DOI:10.1002/anie.202003830

Reference yield: 71.0%

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) + (2-phenylethyl)boronic acid (34420-17-2) → 2-(4-phenylbutyl)pyridine (5520-22-9)

Guidance literature:

With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; In N,N-dimethyl acetamide; at 20 ℃; for 20h; Irradiation;

DOI:10.1021/acscatal.1c02823

Reference yield:

hept-6-ynenitrile (15295-69-9) + acetylene (74-86-2,25067-58-7) → 5,6,7,8-tetrahydroquinoline (10500-57-9) + 2-hex-5-ynyl-pyridine (105905-76-8) + 2-(4-phenylbutyl)pyridine (5520-22-9) + 5-phenylvaleronitrile (7726-45-6) + 2-(4-cyanobutyl)-5,6,7,8-tetrahydroquinoline

Guidance literature:

With triethylaluminum; cobalt(II) 2-ethylhexanoate; In toluene; at 150 ℃; for 8h; under 11400 Torr; Product distribution; reactants' ratio dependence;

DOI:10.1007/BF00954829

upstream raw materials:

α-picoline

phenylpropyl chloride

hept-6-ynenitrile

acetylene