(2S)-2-amino-N-[(2S,5R,7E,9E,11R,13S)-2-amino-5-formyl-13-hydroxy-4-(4-hydroxy-3-iodophenyl)-7,9,11-trimethyl-3,6-dioxotetradeca-7,9-dien-5-yl]-N-methylpropanamide

Base Information

Chemical Name:(2S)-2-amino-N-[(2S,5R,7E,9E,11R,13S)-2-amino-5-formyl-13-hydroxy-4-(4-hydroxy-3-iodophenyl)-7,9,11-trimethyl-3,6-dioxotetradeca-7,9-dien-5-yl]-N-methylpropanamide
CAS No.:108675-63-4
Molecular Formula:C28H40 I N3 O6
Molecular Weight:641.55
Hs Code.:

(2S)-2-amino-N-[(2S,5R,7E,9E,11R,13S)-2-amino-5-formyl-13-hydroxy-4-(4-hydroxy-3-iodophenyl)-7,9,11-trimethyl-3,6-dioxotetradeca-7,9-dien-5-yl]-N-methylpropanamide

Synonyms:geodiamolide A

Suppliers and Price of (2S)-2-amino-N-[(2S,5R,7E,9E,11R,13S)-2-amino-5-formyl-13-hydroxy-4-(4-hydroxy-3-iodophenyl)-7,9,11-trimethyl-3,6-dioxotetradeca-7,9-dien-5-yl]-N-methylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-amino-N-[(2S,5R,7E,9E,11R,13S)-2-amino-5-formyl-13-hydroxy-4-(4-hydroxy-3-iodophenyl)-7,9,11-trimethyl-3,6-dioxotetradeca-7,9-dien-5-yl]-N-methylpropanamide

Chemical Property:

Vapor Pressure:2.21E-20mmHg at 25°C
Boiling Point:696.8°Cat760mmHg
Flash Point:375.2°C
PSA：164.02000
Density:1.386g/cm³
LogP:4.00930
XLogP3:2.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:13
Exact Mass:641.19618
Heavy Atom Count:38
Complexity:938

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC(C)O)C=C(C)C=C(C)C(=O)C(C=O)(C(C1=CC(=C(C=C1)O)I)C(=O)C(C)N)N(C)C(=O)C(C)N
Isomeric SMILES:C[C@H](C[C@H](C)O)/C=C(\C)/C=C(\C)/C(=O)[C@](C=O)(C(C1=CC(=C(C=C1)O)I)C(=O)[C@H](C)N)N(C)C(=O)[C@H](C)N

Technology Process of (2S)-2-amino-N-[(2S,5R,7E,9E,11R,13S)-2-amino-5-formyl-13-hydroxy-4-(4-hydroxy-3-iodophenyl)-7,9,11-trimethyl-3,6-dioxotetradeca-7,9-dien-5-yl]-N-methylpropanamide

There total 66 articles about (2S)-2-amino-N-[(2S,5R,7E,9E,11R,13S)-2-amino-5-formyl-13-hydroxy-4-(4-hydroxy-3-iodophenyl)-7,9,11-trimethyl-3,6-dioxotetradeca-7,9-dien-5-yl]-N-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 127462-55-9
(E)-(3S,6R,9S,12S,16R,18S)-6-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-benzyl]-3,7,9,12,14,16,18-heptamethyl-1-oxa-4,7,10-triaza-cyclooctadec-14-ene-2,5,8,11-tetraone

: 108675-63-4
geodiamolide A

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

Reference yield: 20.0%

: 119326-52-2
(S)-2-((S)-3-(4-Hydroxy-3-iodo-phenyl)-2-{[(S)-2-((E)-(2S,6R,8S)-8-hydroxy-2,4,6-trimethyl-non-4-enoylamino)-propionyl]-methyl-amino}-propionylamino)-propionic acid

: 108675-63-4
geodiamolide A

Guidance literature:: With 4 A molecular sieve; 4-N,N-dimethylaminopyridine trifluoroacetate; dicyclohexyl-carbodiimide; In chloroform; Heating;
DOI:10.1021/jo00265a003

Reference yield:

: 82190-18-9
(S)-(-)-γ-methyl-α-methylene-γ-butyrolactone

: 108675-63-4
geodiamolide A

Guidance literature:: Multi-step reaction with 11 steps

1: 72 percent / H₂ / 10percent Pd/C / ethanol / 25 °C

2: 1.) 2.5 M KOH, 2.) imidazole / 1.) THF, 25 deg C, 2.) DMF, 25 deg C

3: 78 percent / (iBu)2AlH / diethyl ether / 25 °C

4: 75 percent / (COCl)2, Et₃N / dimethylsulfoxide; CH₂Cl₂ / -60 - 25 °C

5: tetrahydrofuran / Heating

6: EtCO₂H / 110 °C

7: 86 percent / LiOH, H₂O / tetrahydrofuran; methanol

8: 57 percent / (PhO)2PON₃, Et₃N / dimethylformamide / 0 - 25 °C

9: 83 percent / 5percent HF / acetonitrile / 25 °C

10: 95 percent / LiOH, H₂O / tetrahydrofuran; methanol / 25 °C

11: 20 percent / DCC, DMAP-TFA, 4-Angstroem molecular sieves / CHCl₃ / Heating

With 1H-imidazole; potassium hydroxide; lithium hydroxide; oxalyl dichloride; 4 A molecular sieve; diphenyl phosphoryl azide; hydrogen fluoride; water; hydrogen; diisobutylaluminium hydride; propionic acid; 4-N,N-dimethylaminopyridine trifluoroacetate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00265a003