N-(tert-butoxycarbonyl)-O-[tert-butyl(dimethyl)silyl]-N-methyl-D-tyrosine

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-O-[tert-butyl(dimethyl)silyl]-N-methyl-D-tyrosine
CAS No.:119706-71-7
Molecular Formula:C₂₁H₃₅NO₅Si
Molecular Weight:409.598
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-O-[tert-butyl(dimethyl)silyl]-N-methyl-D-tyrosine

Suppliers and Price of N-(tert-butoxycarbonyl)-O-[tert-butyl(dimethyl)silyl]-N-methyl-D-tyrosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(tert-butoxycarbonyl)-O-[tert-butyl(dimethyl)silyl]-N-methyl-D-tyrosine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of N-(tert-butoxycarbonyl)-O-[tert-butyl(dimethyl)silyl]-N-methyl-D-tyrosine

There total 4 articles about N-(tert-butoxycarbonyl)-O-[tert-butyl(dimethyl)silyl]-N-methyl-D-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 119706-75-1
(R)-2-(tert-butoxycarbonylamino)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoic acid

: 74-88-4
methyl iodide

: 119706-71-7
N-(tert-butoxycarbonyl)-O-[tert-butyl(dimethyl)silyl]-N-methyl-D-tyrosine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; for 8h; Ambient temperature;
DOI:10.1016/S0040-4039(00)75846-1

Reference yield:

: 70642-86-3
N-(tert-butoxycarbonyl)-D-tyrosine

: 119706-71-7
N-(tert-butoxycarbonyl)-O-[tert-butyl(dimethyl)silyl]-N-methyl-D-tyrosine

Guidance literature:: Multi-step reaction with 2 steps

1: 1) imidazole, 2) K₂CO₃, H₂O / 1) DMF, RT, 48 h, 2) MeOH, THF, RT, 24 h

2: 1) 1,7 M Bu^tLi in pentane / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C to RT, 7.5 h

With 1H-imidazole; water; tert.-butyl lithium; potassium carbonate;
DOI:10.3987/COM-97-S41

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 119706-71-7
N-(tert-butoxycarbonyl)-O-[tert-butyl(dimethyl)silyl]-N-methyl-D-tyrosine

Guidance literature:: Multi-step reaction with 2 steps

1: 1) imidazole, 2) K₂CO₃, H₂O / 1) DMF, RT, 48 h, 2) MeOH, THF, RT, 24 h

2: 1) 1,7 M Bu^tLi in pentane / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C to RT, 7.5 h

With 1H-imidazole; water; tert.-butyl lithium; potassium carbonate;
DOI:10.3987/COM-97-S41