2,4-DIHYDROXY-5-METHYLBENZOIC ACID

Base Information

• Chemical Name: 2,4-DIHYDROXY-5-METHYLBENZOIC ACID
• CAS No.: 4780-64-7
• Molecular Formula: C8H8 O4
• Molecular Weight: 168.149
• Mol file: 4780-64-7.mol

Synonyms:b-Resorcylic acid, 5-methyl-(7CI,8CI); 2,4-Dihydroxy-5-methylbenzoic acid

Chemical Property of 2,4-DIHYDROXY-5-METHYLBENZOIC ACID

Chemical Property:

• Vapor Pressure: 4.63E-07mmHg at 25°C
• Boiling Point: 398.3°Cat760mmHg
• Flash Point: 208.9°C
• PSA: 77.76000
• Density: 1.46g/cm³
• LogP: 1.10440

Purity/Quality:

2,4-Dihydroxy-5-methylbenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2,4-Dihydroxy-5-methylbenzoic acid is a useful reagent in the preparation of substituted dihydroxybenzoic acids which are potential antiinflammatory agents.

Technology Process of 2,4-DIHYDROXY-5-METHYLBENZOIC ACID

There total 4 articles about 2,4-DIHYDROXY-5-METHYLBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methyl resorcinol (496-73-1,73073-80-0) + carbon dioxide (124-38-9,18923-20-1) → 2,4-dihydroxy-5-methylbenzoic acid (4780-64-7)

Guidance literature:

With potassium hydrogencarbonate; In water; at 85 ℃; for 6h;

Reference yield:

4-((4-((5-formyl-4-(methoxycarbonyl)-2-methylphenoxy)carbonyl)-5-methoxy-2,3-dimethylphenoxy)carbonyl)-5-hydroxy-2-methylphenyl-3-formyl-4-hydroxy-2-methoxy-6-methylbenzoate → 2,4-dihydroxy-5-methylbenzoic acid (4780-64-7) + methyl 2-formyl-4-hydroxy-5-methylbenzoate + 3-formyl-4-hydroxy-2-methoxy-6-methylbenzoic acid + 4-hydroxy-6-methoxy-2,3-dimethylbenzoic acid

Guidance literature:

With potassium hydroxide; In methanol; water; Reflux;

DOI:10.14233/ajchem.2019.21734

Reference yield:

2,4-Dihydroxybenzaldehyde (95-01-2) → 2,4-dihydroxy-5-methylbenzoic acid (4780-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; sodium cyanoborohydride / tetrahydrofuran / 3 h / 20 °C

2: potassium hydrogencarbonate / water / 6 h / 85 °C

With hydrogenchloride; sodium cyanoborohydride; potassium hydrogencarbonate; In tetrahydrofuran; water;

upstream raw materials:

4-methyl resorcinol

carbon dioxide

2,4-Dihydroxybenzaldehyde

Downstream raw materials:

methyl 2,4-dimethoxy-5-methylbenzoate