Technology Process of Phosphoric acid,
[(4R)-4,5-dihydro-4-[2-(4-octylphenyl)ethyl]-2-(trichloromethyl)-4-oxazolyl
]methyl bis(1,1-dimethylethyl) ester
There total 7 articles about Phosphoric acid,
[(4R)-4,5-dihydro-4-[2-(4-octylphenyl)ethyl]-2-(trichloromethyl)-4-oxazolyl
]methyl bis(1,1-dimethylethyl) ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S)-2-(2'-(trichloromethyl)-4',5'-dihydrooxazol-5-yl)-4-(4''-octylphenyl)-butan-1-ol; di-tert-butyl diisopropylphosphoramide;
With
1H-tetrazole;
In
dichloromethane; acetonitrile;
for 6h;
With
tert.-butylhydroperoxide;
at 20 ℃;
DOI:10.1016/j.tetlet.2005.11.092
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-BuLi / tetrahydrofuran
1.2: 81 percent / H2 / Pd(OH)2/C / methanol
2.1: PCC; NaOAc; molecular sieves / CH2Cl2
2.2: 76 percent / Et3N / CH2Cl2
3.1: 87 percent / NaBH4 / CeCl3 / methanol
4.1: 83 percent / (+)-DIPT; cumene hydroperoxide; MS / Ti(OPr-i)4 / CH2Cl2 / -20 °C
5.1: DBU / CH2Cl2 / 1.5 h / 0 °C
5.2: 74 percent / Et2AlCl / CH2Cl2 / 0 - 20 °C
6.1: 1H-tetrazole / CH2Cl2; acetonitrile / 6 h
6.2: 78 percent / t-BuOOH / 20 °C
With
1H-tetrazole; sodium tetrahydroborate; n-butyllithium; molecular sieve; L-(+)-diisopropyl tartrate; Cumene hydroperoxide; sodium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridinium chlorochromate;
titanium(IV) isopropylate; cerium(III) chloride;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
1.1: Wittig reaction / 2.2: Mannich reaction / 4.1: asymmetric Sharpless epoxidation;
DOI:10.1016/j.tetlet.2005.11.092
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 87 percent / NaBH4 / CeCl3 / methanol
2.1: 83 percent / (+)-DIPT; cumene hydroperoxide; MS / Ti(OPr-i)4 / CH2Cl2 / -20 °C
3.1: DBU / CH2Cl2 / 1.5 h / 0 °C
3.2: 74 percent / Et2AlCl / CH2Cl2 / 0 - 20 °C
4.1: 1H-tetrazole / CH2Cl2; acetonitrile / 6 h
4.2: 78 percent / t-BuOOH / 20 °C
With
1H-tetrazole; sodium tetrahydroborate; L-(+)-diisopropyl tartrate; Cumene hydroperoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene;
titanium(IV) isopropylate; cerium(III) chloride;
In
methanol; dichloromethane; acetonitrile;
2.1: asymmetric Sharpless epoxidation;
DOI:10.1016/j.tetlet.2005.11.092
