2-Propenoic acid, 3-[1-[(2-methoxyethoxy)methyl]-2-(1-oxo-3,3-diphenylpropyl)-1H-imidaz ol-4-yl]-, methyl ester, (2E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-[1-[(2-methoxyethoxy)methyl]-2-(1-oxo-3,3-diphenylpropyl)-1H-imidaz ol-4-yl]-, methyl ester, (2E)-
• CAS No.: 876404-23-8
• Molecular Formula: C26H28N2O5
• Molecular Weight: 448.519
• Mol file: 876404-23-8.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 3-[1-[(2-methoxyethoxy)methyl]-2-(1-oxo-3,3-diphenylpropyl)-1H-imidaz ol-4-yl]-, methyl ester, (2E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenoic acid, 3-[1-[(2-methoxyethoxy)methyl]-2-(1-oxo-3,3-diphenylpropyl)-1H-imidaz ol-4-yl]-, methyl ester, (2E)-

There total 2 articles about 2-Propenoic acid, 3-[1-[(2-methoxyethoxy)methyl]-2-(1-oxo-3,3-diphenylpropyl)-1H-imidaz ol-4-yl]-, methyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

N-methoxy-N-methyl-3,3-diphenylpropanamide (166337-41-3) + 3-[1-(2-methoxy-ethoxymethyl)-1H-imidazol-4-yl]-acrylic acid methyl ester (876404-22-7) → 3-[2-(3,3-diphenyl-propionyl)-1-(2-methoxy-ethoxymethyl)-1H-imidazol-4-yl]-acrylic acid methyl ester (876404-23-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2005.10.030

Reference yield:

(E)-methyl 3-(1H-imidazol-4-yl)acrylate (70346-51-9) → 3-[2-(3,3-diphenyl-propionyl)-1-(2-methoxy-ethoxymethyl)-1H-imidazol-4-yl]-acrylic acid methyl ester (876404-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylsulfoxide / 6 h / 0 - 80 °C

2: 48 percent / LDA / tetrahydrofuran / 2 h / 0 - 20 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2005.10.030

Reference yield: 98.0%

3-[2-(3,3-diphenyl-propionyl)-1-(2-methoxy-ethoxymethyl)-1H-imidazol-4-yl]-acrylic acid methyl ester (876404-23-8) → 3-[2-(3,3-diphenyl-propionyl)-1-(2-methoxy-ethoxymethyl)-1H-imidazol-4-yl]-propionic acid methyl ester (876404-39-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2005.10.030

upstream raw materials:

N-methoxy-N-methyl-3,3-diphenylpropanamide

3-[1-(2-methoxy-ethoxymethyl)-1H-imidazol-4-yl]-acrylic acid methyl ester

(E)-methyl 3-(1H-imidazol-4-yl)acrylate

Downstream raw materials:

3-[2-(3,3-diphenyl-propionyl)-1-(2-methoxy-ethoxymethyl)-1H-imidazol-4-yl]-propionic acid methyl ester

2-tert-butoxycarbonylamino-3-[2-(3,3-diphenyl-propionyl)-1-(2-methoxy-ethoxymethyl)-1H-imidazol-4-yl]-3-hydroxy-propionic acid methyl ester

1-[4-(2-amino-ethyl)-1-(2-methoxy-ethoxymethyl)-1H-imidazol-2-yl]-3,3-diphenyl-propan-1-one

3-[2-(3,3-diphenyl-propionyl)-1-(2-methoxy-ethoxymethyl)-1H-imidazol-4-yl]-propionic acid