2-Hydroxy-3-methoxybenzyl alcohol

Base Information

• Chemical Name: 2-Hydroxy-3-methoxybenzyl alcohol
• CAS No.: 4383-05-5
• Molecular Formula: C8H10O3
• Molecular Weight: 154.166
• Hs Code.: 2909500000
• European Community (EC) Number: 224-488-1
• DSSTox Substance ID: DTXSID80195948
• Nikkaji Number: J205.759J
• Wikidata: Q72484766
• ChEMBL ID: CHEMBL3786715
• Mol file: 4383-05-5.mol

Synonyms:2-Hydroxy-3-methoxybenzyl alcohol;2-(Hydroxymethyl)-6-methoxyphenol;4383-05-5;3-Methoxysalicyl alcohol;Benzenemethanol, 2-hydroxy-3-methoxy-;2-(hydroxymethyl)-6-methoxy-phenol;o-Vanillyl alcohol;OKE;SCHEMBL828720;2-hydroxymethyl-6-methoxyphenol;CHEMBL3786715;DTXSID80195948;2-hydroxy-3-methoxybenzenemethanol;2-Methoxy-6-(hydroxymethyl)phenol;2-Hydroxy-3-(hydroxymethyl)anisole;EINECS 224-488-1;MFCD00008362;2-(Hydroxymethyl)-6-methoxyphenol #;AKOS000248911;AC-6161;2-Hydroxy-3-methoxybenzyl alcohol, 97%;AS-61261;AM20040478;CS-0150322;FT-0602165;H1273;EN300-698225;A826428

Chemical Property of 2-Hydroxy-3-methoxybenzyl alcohol

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 8.98E-06mmHg at 25°C
• Melting Point: 61-63 °C(lit.)
• Refractive Index: 1.57
• Boiling Point: 358.817 °C at 760 mmHg
• PKA: 9.93±0.10(Predicted)
• Flash Point: 115.628 °C
• PSA: 49.69000
• Density: 1.227 g/cm³
• LogP: 0.89310
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 154.062994177
• Heavy Atom Count: 11
• Complexity: 116

Purity/Quality:

97% ^*data from raw suppliers

2-Hydroxy-3-methoxybenzyl Alcohol >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=CC(=C1O)CO
• Uses: 2-Hydroxy-3-methoxybenzyl alcohol was employed as substrate, to investigate in vitro substrate specificity of UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase from Sorghum bicolor (UGT85B1).

Technology Process of 2-Hydroxy-3-methoxybenzyl alcohol

There total 12 articles about 2-Hydroxy-3-methoxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) → 2-hydroxy-3-methoxybenzyl alcohol (4383-05-5)

Guidance literature:

With hydrogen; nickel; In ethanol; for 48h; under 2327.2 Torr; Ambient temperature;

DOI:10.1021/jo00221a019

Reference yield: 88.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-methoxy-phenol (90-05-1) → 2-hydroxy-3-methoxybenzyl alcohol (4383-05-5)

Guidance literature:

With sodium metaborate tetrahydrate; In water; at 40 ℃; for 12h; regioselective reaction; Green chemistry;

DOI:10.1039/c4ob00228h

Reference yield: 65.0%

3-methoxysalicylic acid (877-22-5) → 2-hydroxy-3-methoxybenzyl alcohol (4383-05-5)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1002/(SICI)1099-0690(199805)1998:5<837::AID-EJOC837>3.0.CO;2-7

upstream raw materials:

3-methoxy-2-hydroxybenzaldehyde

8-methoxy-2-phenyl-4H-benzo[1,3,2]dioxaborinine

3-methoxybenzyl alcohol

5-Fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(8-methoxy-2-oxo-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Downstream raw materials:

(2-hydroxy-3-methoxy-phenyl)-methanesulfonic acid

2-methyl-6-methoxyphenol

2-methoxy-6-hydroxymethyl-1,4-benzoquinone

2-methoxy-3-methylbenzaldehyde