10.1039/c5ra25071d
The research presented in the "RSC Advances" manuscript focuses on the synthesis and in vivo assessment of newly synthesized achiral copper(II) and zinc(II) complexes derived from benzimidazole. The study aimed to evaluate their potential as analgesic, antipyretic, and anti-inflammatory agents. The reactants used in the synthesis include 2-aminobenzimidazole, o-vanillin, Cu(NO3)2·3H2O, and Zn(NO3)2·6H2O. The Schiff base ligand was synthesized by refluxing 2-aminobenzimidazole and o-vanillin in absolute ethanol, followed by recrystallization. The copper(II) and zinc(II) complexes were then synthesized by reacting the Schiff base with the respective metal nitrate salts in methanol. Characterization of the ligand and complexes was performed using various analytical and spectroscopic techniques, including infrared (IR), proton (1H) and carbon-13 (13C) nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR), high-resolution mass spectrometry (HRMS), and ultra-performance liquid chromatography (UPLC). The in vivo biological activities were assessed using mice and rats models for antipyretic (yeast-induced hyperpyrexia), analgesic (acetic acid-induced writhing), and anti-inflammatory (carrageenan-induced paw edema) effects. The experiments were conducted following ethical guidelines, and the results were statistically analyzed using one-way ANOVA and Dunnett's post-hoc test.
10.1016/S0040-4020(98)00975-2
The research focuses on the synthesis of the antitumor alkaloid (+)-pancratistatin, a compound isolated from the Hawaiian plant Pancratium littorale, which shows significant potential as a clinically useful antitumor agent. The study aims to develop a reliable and efficient synthetic route to (+)-pancratistatin due to the limited natural supply of the alkaloid. The synthesis process involves a series of chemical reactions, including dehydration, hydrogenation, hydrolysis, and the use of the [3-azidonation reaction on triisopropylsilyl (TIPS) enol ethers, leading to the formation of the key intermediates and ultimately (+)-pancratistatin. Key chemicals used in the synthesis include o-vanillin, n-BuLi/TI-IF, POCI3/pyridine/DBU, LiAlH4, MCPBA, KOBut/HMPA, and various other reagents and solvents. The successful synthesis was achieved in 22 steps from commercially available o-vanillin with an overall yield of 1.2%, marking a significant advancement in the field of alkaloid chemistry and potentially providing a more accessible source of this important antitumor agent.
10.1016/j.molstruc.2019.127635
The research aimed to synthesize and evaluate a series of octahedral homoleptic tin(IV) compounds derived from tridentate ONS dithiocarbazate Schiff bases for their potential cytotoxic effects against various cancer cell lines. The key chemicals used in the synthesis included tin(II) chloride, dithiocarbazate Schiff bases derived from 2-hydroxy-3-methoxybenzaldehyde and 2,3-dihydroxybenzaldehyde, and various substituted benzyl groups. The compounds were characterized using elemental analysis, FT-IR, multinuclear NMR (1H, 13C, and 119Sn), and X-ray crystallography. Density functional theory (DFT) calculations were employed to validate the experimental findings. The study concluded that five of the synthesized tin(IV) compounds exhibited higher cytotoxicity against HT29, MCF7, and MIA cancer cell lines compared to the reference drug cisplatin, suggesting their potential as chemotherapeutic agents. The research highlights the significance of ligand modification in enhancing the bioactivity of metal-based compounds for cancer therapy.
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