pyrrolidino-benzylphenoxyethanamine

Base Information

• Chemical Name: pyrrolidino-benzylphenoxyethanamine
• CAS No.: 147664-41-3
• Molecular Formula: C₁₉H₂₃NO
• Molecular Weight: 281.398
• Mol file: 147664-41-3.mol

Synonyms:PBPE

Chemical Property of pyrrolidino-benzylphenoxyethanamine

Chemical Property:

• Vapor Pressure: 3E-07mmHg at 25°C
• Boiling Point: 419.6°Cat760mmHg
• Flash Point: 123.1°C
• PSA: 12.47000
• Density: 1.061g/cm³
• LogP: 3.68990

Purity/Quality:

99% ^*data from raw suppliers

1-[2-[4-(PHENYLMETHYL)PHENOXY]ETHYL]PYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of pyrrolidino-benzylphenoxyethanamine

There total 7 articles about pyrrolidino-benzylphenoxyethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyrrolidine (123-75-1) + 2-(4-benzylphenoxy)ethylbromine (165683-41-0) → 1-[2-[4-(phenylmethyl)phenoxy]ethyl]-pyrrolidine (147664-41-3)

Guidance literature:

In N,N-dimethyl-formamide; at 60 ℃; for 12h;

Reference yield: 69.0%

p-benzylphenol (101-53-1) + 1-(2-chloroethyl)pyrrolidine hydrochloride (7250-67-1) → 1-[2-[4-(phenylmethyl)phenoxy]ethyl]-pyrrolidine (147664-41-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 90 ℃;

DOI:10.1021/jm990496z

Reference yield:

pyrrolidine (123-75-1) + 2-[4-(phenylmethyl)phenoxy]ethyl 4-methylbenzenesulfonate (60225-65-2) → 1-[2-[4-(phenylmethyl)phenoxy]ethyl]-pyrrolidine (147664-41-3)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; Heating;

DOI:10.1016/S0960-894X(02)00760-6

upstream raw materials:

p-benzylphenol

1-(2-chloroethyl)pyrrolidine hydrochloride

pyrrolidine

2-[4-(phenylmethyl)phenoxy]ethyl 4-methylbenzenesulfonate

Refernces

• 1、 Penning, Thomas D.,Chandrakumar, Nizal S.,Desai, Bipin N.,Djuric, Stevan W.,Gasiecki, Alan F.,Malecha, James W.,Miyashiro, Julie M.,Russell, Mark A.,Askonas, Leslie J.,Gierse, James K.,Harding, Elizabeth I.,Highkin, Maureen K.,Kachur, James F.,Kim, Suzanne H.,Villani-Price, Doreen,Pyla, E. Yvonne,Ghoreishi-Haack, Nayereh S.,Smith, Walter G.. "Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase". . p. 1137 - 1139. Retrieved 2007/10/03.
• 2、 Penning, Thomas D.,Chandrakumar, Nizal S.,Desai, Bipin N.,Djuric, Stevan W.,Gasiecki, Alan F.,Liang, Chi-Dean,Miyashiro, Julie M.,Russell, Mark A.,Askonas, Leslie J.,Gierse, James K.,Harding, Elizabeth I.,Highkin, Maureen K.,Kachur, James F.,Kim, Suzanne H.,Villani-Price, Doreen,Pyla,Ghoreishi-Haack, Nayereh S.,Smith, Walter G.. "Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A4 hydrolase". . p. 3383 - 3386. Retrieved 2007/10/03.