tert-Butyl 4-(3,3-difluoropyrrolidin-1-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 4-(3,3-difluoropyrrolidin-1-yl)piperidine-1-carboxylate
• CAS No.: 877125-71-8
• Molecular Formula: C₁₄H₂₄F₂N₂O₂
• Molecular Weight: 290.354
• Hs Code.: 2933990090
• Mol file: 877125-71-8.mol

Synonyms:4-(3,3-difluoro-pyrrolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester;

Chemical Property of tert-Butyl 4-(3,3-difluoropyrrolidin-1-yl)piperidine-1-carboxylate

Chemical Property:

• PSA: 32.78000
• LogP: 2.60270
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl 4-(3,3-difluoropyrrolidin-1-yl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 4-(3,3-difluoropyrrolidin-1-yl)piperidine-1-carboxylate

There total 1 articles about tert-Butyl 4-(3,3-difluoropyrrolidin-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 3,3-difluoropyrrolidine hydrochloride (163457-23-6) → 4-(3,3-difluoro-pyrrolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (877125-71-8)

Guidance literature:

N-tert-butyloxycarbonylpiperidin-4-one; 3,3-difluoropyrrolidine hydrochloride; With titanium(IV) isopropylate; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium cyanoborohydride; In tetrahydrofuran; ethanol; for 17h;

With sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water;

Reference yield:

4-(3,3-difluoro-pyrrolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (877125-71-8) → 4-(3,3-difluoro-pyrrolidin-1-yl)piperidine hydrochloride (1956310-36-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

3,3-difluoropyrrolidine hydrochloride

Downstream raw materials:

4-(3,3-difluoro-pyrrolidin-1-yl)piperidine hydrochloride

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