Thiophen-2-ol

Base Information

• Chemical Name: Thiophen-2-ol
• CAS No.: 17236-58-7
• Molecular Formula: C4H4OS
• Molecular Weight: 100.14
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID90447920
• Nikkaji Number: J1.137.835H
• Wikidata: Q82266819
• Mol file: 17236-58-7.mol

Synonyms:Thiophen-2-ol;17236-58-7;Thiophene-2-ol;2-HYDROXYTHIOPHENE;hydroxythiophene;2-hydroxy thiophene;hydroxythiophen;thienyl alcohol;2-thiophenol;2-Thiopheneol;2-hydroxy-thiophene;SCHEMBL9016;DTXSID90447920;2-Hydroxythiophene;BCP31895;AC4704;MFCD01075765;AKOS016371239;SY248518;FT-0731087;EN300-127777

Chemical Property of Thiophen-2-ol

Chemical Property:

• Melting Point: 9°C
• Refractive Index: 1.5644 (estimate)
• Boiling Point: 219.2 °C at 760 mmHg
• PKA: 8.43±0.10(Predicted)
• Flash Point: 86.4 °C
• PSA: 48.47000
• Density: 1.294 g/cm³
• LogP: 1.45370
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 99.99828592
• Heavy Atom Count: 6
• Complexity: 46.8

Purity/Quality:

98%Min ^*data from raw suppliers

thiophen-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)O

Technology Process of Thiophen-2-ol

There total 9 articles about Thiophen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

thiophene boronic acid (6165-68-0) → thiophen-2-ol (17236-58-7)

Guidance literature:

With dihydrogen peroxide; In water; at 20 ℃; chemoselective reaction;

DOI:10.1016/j.apcata.2018.05.037

Reference yield: 95.0%

2-thiopheneboronic acid pinacol ester (193978-23-3) → thiophen-2-ol (17236-58-7)

Guidance literature:

With copper ferrite; oxygen; In water; at 27 ℃; for 0.666667h;

DOI:10.1080/00958972.2020.1802437

Reference yield: 88.0%

2-Iodothiophene (3437-95-4,149762-92-5) → thiophen-2-ol (17236-58-7)

Guidance literature:

With copper(l) iodide; potassium hydroxide; In water; at 100 ℃; Inert atmosphere;

DOI:10.1016/j.catcom.2011.06.002

upstream raw materials:

2,5-dihydro-2H-2-oxothiophene

thiophene

Trimethyl borate

thiophene boronic acid

Downstream raw materials:

5-benzylidene-5H-thiophen-2-one

thiophen-2-yl benzoate

N-(4-Nitro-2-(benzothiophen-5'-yloxy)phenyl)methanesulfonamide

2,5-dihydro-2H-2-oxothiophene

Refernces

• 1、 Cong, Hang,Yamato, Takehiko,Tao, Zhu. "Hemicucurbit[6]uril-induced aerobic oxidation of heterocyclic compounds". . p. 287 - 293. Retrieved 2013.
• 2、 Chutia, Rituparna,Chetia, Bolin. "An efficient base and H2O2 free protocol for the synthesis of phenols in water and oxygen using spinel CuFe2O4 magnetic nanoparticles". . p. 1925 - 1936. Retrieved 2020/08/13.
• 3、 -. "BIARYL PHENOXY GROUP IV TRANSITION METAL CATALYSTS FOR OLEFIN POLYMERIZATION". . . Retrieved 2020/05/14.