Technology Process of Ethanone, 1-[4-(3,3,3-trifluoro-1-propynyl)phenyl]-
There total 3 articles about Ethanone, 1-[4-(3,3,3-trifluoro-1-propynyl)phenyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(trifluoromethyl)trimethylsilane;
With
1,10-Phenanthroline; potassium tert-butylate; silver carbonate; copper(l) chloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
Molecular sieve;
Inert atmosphere;
4-ethynylacetophenone;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 5h;
Inert atmosphere;
DOI:10.1002/ejoc.201101550
- Guidance literature:
-
(trifluoromethyl)trimethylsilane;
With
potassium fluoride; copper(l) iodide; 1,10-Phenanthroline; silver carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
Inert atmosphere;
Glovebox;
3-(4-acetylphenyl)propiolic acid;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 6h;
Inert atmosphere;
Glovebox;
DOI:10.1016/j.tet.2016.05.012
- Guidance literature:
-
With
potassium fluoride;
In
N,N-dimethyl-formamide;
at 100 ℃;
for 1h;
Schlenk technique;
Inert atmosphere;
DOI:10.1039/c8dt00291f
