Cyclohexanecarboxylic acid, 4-[[(2S,5S)-1-[[7-fluoro-2-[(5-fluoro-2-methylphenyl)amino]-6-benzoxazol yl]acetyl]-5-(2-isoxazolidinylmethyl)-2-pyrrolidinyl]methoxy]-, trans-

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Chemical Name:Cyclohexanecarboxylic acid, 4-[[(2S,5S)-1-[[7-fluoro-2-[(5-fluoro-2-methylphenyl)amino]-6-benzoxazol yl]acetyl]-5-(2-isoxazolidinylmethyl)-2-pyrrolidinyl]methoxy]-, trans-
CAS No.:877665-34-4
Molecular Formula:C32H38F2N4O6
Molecular Weight:612.674
Hs Code.:

Cyclohexanecarboxylic acid,
4-[[(2S,5S)-1-[[7-fluoro-2-[(5-fluoro-2-methylphenyl)amino]-6-benzoxazol
yl]acetyl]-5-(2-isoxazolidinylmethyl)-2-pyrrolidinyl]methoxy]-, trans-

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Chemical Property of Cyclohexanecarboxylic acid, 4-[[(2S,5S)-1-[[7-fluoro-2-[(5-fluoro-2-methylphenyl)amino]-6-benzoxazol yl]acetyl]-5-(2-isoxazolidinylmethyl)-2-pyrrolidinyl]methoxy]-, trans-

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Technology Process of Cyclohexanecarboxylic acid, 4-[[(2S,5S)-1-[[7-fluoro-2-[(5-fluoro-2-methylphenyl)amino]-6-benzoxazol yl]acetyl]-5-(2-isoxazolidinylmethyl)-2-pyrrolidinyl]methoxy]-, trans-

There total 9 articles about Cyclohexanecarboxylic acid, 4-[[(2S,5S)-1-[[7-fluoro-2-[(5-fluoro-2-methylphenyl)amino]-6-benzoxazol yl]acetyl]-5-(2-isoxazolidinylmethyl)-2-pyrrolidinyl]methoxy]-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 877665-36-6
ethyl trans-4-[1-[[7-fluoro-2-(5-fluoro-2-methylphenylamino)-6-benzoxazolyl]acetyl]-(5S)-(1-isoxazolidinylmethyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

: 877665-34-4
C₃₂H₃₈F₂N₄O₆

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 20h;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: ethyl 4-[(5S)-benzyloxymethyl-1-tert-butoxycarbonyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

: 877665-34-4
C₃₂H₃₈F₂N₄O₆

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydride / N,N-dimethyl-formamide; ethanol / 0.67 h / 0 °C

2: potassium carbonate / water / 0.5 h / 70 °C

3: hydrogen; palladium(II) hydroxide / acetic acid; ethanol / 20 °C / 1?atm

4: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.5 h / 0 - 20 °C

5: sodium tris(acetoxy)borohydride / tetrahydrofuran / 2.5 h / 20 °C

6: hydrogenchloride; water / 1,4-dioxane / 3 h

7: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 72 h

8: water; sodium hydroxide / tetrahydrofuran / 20 h / 20 °C

With hydrogenchloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; water; hydrogen; palladium(II) hydroxide; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 877664-92-1
ehyl trans-4-[1-tert-butoxycarbonyl-(5S)-formyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

: 877665-34-4
C₃₂H₃₈F₂N₄O₆

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 2.5 h / 20 °C

2: hydrogenchloride; water / 1,4-dioxane / 3 h

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 72 h

4: water; sodium hydroxide / tetrahydrofuran / 20 h / 20 °C

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.003