Cyclohexanecarboxylic acid, 4-[[(2S,5S)-1-[[7-fluoro-2-[(5-fluoro-2-methylphenyl)amino]-6-benzoxazol yl]acetyl]-5-(2-isoxazolidinylmethyl)-2-pyrrolidinyl]methoxy]-, ethyl ester, trans-

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Chemical Name:Cyclohexanecarboxylic acid, 4-[[(2S,5S)-1-[[7-fluoro-2-[(5-fluoro-2-methylphenyl)amino]-6-benzoxazol yl]acetyl]-5-(2-isoxazolidinylmethyl)-2-pyrrolidinyl]methoxy]-, ethyl ester, trans-
CAS No.:877665-36-6
Molecular Formula:C34H42F2N4O6
Molecular Weight:640.727
Hs Code.:

Cyclohexanecarboxylic acid,
4-[[(2S,5S)-1-[[7-fluoro-2-[(5-fluoro-2-methylphenyl)amino]-6-benzoxazol
yl]acetyl]-5-(2-isoxazolidinylmethyl)-2-pyrrolidinyl]methoxy]-, ethyl ester,
trans-

Synonyms:

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Chemical Property of Cyclohexanecarboxylic acid, 4-[[(2S,5S)-1-[[7-fluoro-2-[(5-fluoro-2-methylphenyl)amino]-6-benzoxazol yl]acetyl]-5-(2-isoxazolidinylmethyl)-2-pyrrolidinyl]methoxy]-, ethyl ester, trans-

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Technology Process of Cyclohexanecarboxylic acid, 4-[[(2S,5S)-1-[[7-fluoro-2-[(5-fluoro-2-methylphenyl)amino]-6-benzoxazol yl]acetyl]-5-(2-isoxazolidinylmethyl)-2-pyrrolidinyl]methoxy]-, ethyl ester, trans-

There total 10 articles about Cyclohexanecarboxylic acid, 4-[[(2S,5S)-1-[[7-fluoro-2-[(5-fluoro-2-methylphenyl)amino]-6-benzoxazol yl]acetyl]-5-(2-isoxazolidinylmethyl)-2-pyrrolidinyl]methoxy]-, ethyl ester, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 441714-46-1
[2-(5-fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetic acid

: ethyl trans-4-[(5S)-(1-isoxazolidinylmethyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate dihydrochloride

: 877665-36-6
ethyl trans-4-[1-[[7-fluoro-2-(5-fluoro-2-methylphenylamino)-6-benzoxazolyl]acetyl]-(5S)-(1-isoxazolidinylmethyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; for 72h;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 138528-06-0
(2S,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-2-hydroxymethylpyrrolidine

: 877665-36-6
ethyl trans-4-[1-[[7-fluoro-2-(5-fluoro-2-methylphenylamino)-6-benzoxazolyl]acetyl]-(5S)-(1-isoxazolidinylmethyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 13 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / 2 h / 60 °C

2: hydrogen; palladium(II) hydroxide / acetic acid; ethanol / 120 h / 20 °C / 1?atm

3: trifluoroacetic acid / dichloromethane / 0.67 h / 0 - 20 °C

4: Rh/Al₂O₃; trifluoroacetic acid; hydrogen / acetic acid; ethanol / 20 °C / 10?atm

5: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

6: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 °C

7: sodium hydride / N,N-dimethyl-formamide; ethanol / 0.67 h / 0 °C

8: potassium carbonate / water / 0.5 h / 70 °C

9: hydrogen; palladium(II) hydroxide / acetic acid; ethanol / 20 °C / 1?atm

10: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.5 h / 0 - 20 °C

11: sodium tris(acetoxy)borohydride / tetrahydrofuran / 2.5 h / 20 °C

12: hydrogenchloride; water / 1,4-dioxane / 3 h

13: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 72 h

With hydrogenchloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; di-isopropyl azodicarboxylate; trichloroisocyanuric acid; Rh/Al₂O₃; water; hydrogen; palladium(II) hydroxide; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; 1: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 1416961-30-2
ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-benzyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

: 877665-36-6
ethyl trans-4-[1-[[7-fluoro-2-(5-fluoro-2-methylphenylamino)-6-benzoxazolyl]acetyl]-(5S)-(1-isoxazolidinylmethyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; palladium(II) hydroxide / acetic acid; ethanol / 20 °C / 1?atm

2: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.5 h / 0 - 20 °C

3: sodium tris(acetoxy)borohydride / tetrahydrofuran / 2.5 h / 20 °C

4: hydrogenchloride; water / 1,4-dioxane / 3 h

5: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 72 h

With hydrogenchloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; water; hydrogen; palladium(II) hydroxide; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.003