ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-benzyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Base Information

Chemical Name:ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-benzyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate
CAS No.:1416961-30-2
Molecular Formula:C₂₇H₄₁NO₆
Molecular Weight:475.626
Hs Code.:

Synonyms:ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-benzyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

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Chemical Property of ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-benzyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

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Technology Process of ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-benzyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

There total 5 articles about ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-benzyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₃₇NO₆

: 75-03-6
ethyl iodide

: 1416961-30-2
ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-benzyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: With potassium carbonate; In water; at 70 ℃; for 0.5h;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 1416961-17-5
ethyl 4-[(5S)-benzyloxymethyl-1-tert-butoxycarbonyl-(2S)-pyrrolidinylmethoxy]benzoate

: 1416961-30-2
ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-benzyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen; palladium(II) hydroxide / acetic acid; ethanol / 120 h / 20 °C / 1?atm

2: trifluoroacetic acid / dichloromethane / 0.67 h / 0 - 20 °C

3: Rh/Al₂O₃; trifluoroacetic acid; hydrogen / acetic acid; ethanol / 20 °C / 10?atm

4: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

5: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 °C

6: sodium hydride / N,N-dimethyl-formamide; ethanol / 0.67 h / 0 °C

7: potassium carbonate / water / 0.5 h / 70 °C

With Rh/Al₂O₃; hydrogen; palladium(II) hydroxide; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: C₁₅H₂₇NO₄

: 1416961-30-2
ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-benzyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 °C

3: sodium hydride / N,N-dimethyl-formamide; ethanol / 0.67 h / 0 °C

4: potassium carbonate / water / 0.5 h / 70 °C

With sodium hydride; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.003