Propan-2-yl [methyl(diphenyl)silyl]acetate

Base Information

Chemical Name:Propan-2-yl [methyl(diphenyl)silyl]acetate
CAS No.:87776-13-4
Molecular Formula:C18H22O2Si
Molecular Weight:298.45200
Hs Code.:
DSSTox Substance ID:DTXSID20526555
Wikidata:Q82395103

Synonyms:87776-13-4;ISOPROPYL 2-(METHYLDIPHENYLSILYL)ACETATE;Propan-2-yl [methyl(diphenyl)silyl]acetate;DTXSID20526555

Suppliers and Price of Propan-2-yl [methyl(diphenyl)silyl]acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Propan-2-yl [methyl(diphenyl)silyl]acetate

Chemical Property:

PSA：26.30000
LogP:2.83100
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:298.138906475
Heavy Atom Count:21
Complexity:310

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)OC(=O)C[Si](C)(C1=CC=CC=C1)C2=CC=CC=C2

Technology Process of Propan-2-yl [methyl(diphenyl)silyl]acetate

There total 3 articles about Propan-2-yl [methyl(diphenyl)silyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 92177-88-3
(methyldiphenylsilyl)ketene

: 67-63-0,8013-70-5
isopropyl alcohol

: 87776-13-4
isopropyl-α-methyldiphenylsilyl acetate

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1021/acs.joc.9b01859 DOI:10.1021/acs.joc.9b01859

Reference yield: 48.0%

: 108-21-4
Isopropyl acetate

: 144-79-6
chloromethyldiphenylsilane

: 87776-13-4
isopropyl-α-methyldiphenylsilyl acetate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; 1.) -78 deg C, 40 min, 2.) -78 deg C, 1 h, room temperature;

Reference yield:

: 144-79-6
chloromethyldiphenylsilane

: 87776-13-4
isopropyl-α-methyldiphenylsilyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / ethylbenzene; hexane; tetrahydrofuran / 3 h / -78 - 20 °C / Inert atmosphere

1.2: 4 h / 20 °C / Inert atmosphere

2.1: boron trifluoride diethyl etherate / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

With boron trifluoride diethyl etherate; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; ethylbenzene;
DOI:10.1021/acs.joc.9b01859