Cyclopropanecarboxylic acid, 2-[1-[(2,4-dichlorophenyl)methyl]-6-(trifluoromethyl)-1H-indazol-3-yl]-

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 2-[1-[(2,4-dichlorophenyl)methyl]-6-(trifluoromethyl)-1H-indazol-3-yl]-
• CAS No.: 877768-45-1
• Molecular Formula: C19H13Cl2F3N2O2
• Molecular Weight: 429.226
• Mol file: 877768-45-1.mol

Synonyms:

Chemical Property of Cyclopropanecarboxylic acid, 2-[1-[(2,4-dichlorophenyl)methyl]-6-(trifluoromethyl)-1H-indazol-3-yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropanecarboxylic acid, 2-[1-[(2,4-dichlorophenyl)methyl]-6-(trifluoromethyl)-1H-indazol-3-yl]-

There total 10 articles about Cyclopropanecarboxylic acid, 2-[1-[(2,4-dichlorophenyl)methyl]-6-(trifluoromethyl)-1H-indazol-3-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid (877766-45-5) + diiodomethane (75-11-6) → trans-2-[1-(2,4-dichloro-benzyl)-6-trifluoromethyl-1H-indazol-3-yl]-cyclopropanecarboxylic acid (877768-45-1)

Guidance literature:

zinc-copper couple; In diethyl ether; for 48h; Reflux;

Reference yield:

dimethyl 2-(2-nitro-4-trifluoromethylphenyl)malonate (290825-52-4) → trans-2-[1-(2,4-dichloro-benzyl)-6-trifluoromethyl-1H-indazol-3-yl]-cyclopropanecarboxylic acid (877768-45-1)

Guidance literature:

Multi-step reaction with 9 steps

1.1: dimethyl sulfoxide; sodium chloride / water / 120 °C

2.1: hydrogen / 5% Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr

3.1: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice

4.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 90 °C

5.1: diisobutylaluminium hydride / dichloromethane / 2.25 h / -78 °C / Inert atmosphere

5.2: -78 °C

6.1: manganese(IV) oxide / dichloromethane / 20 °C

7.1: dichloromethane / Reflux

8.1: water; lithium hydroxide / tetrahydrofuran; methanol / 40 °C

8.2: 0 °C / pH 2

9.1: zinc-copper couple / diethyl ether / 48 h / Reflux

With manganese(IV) oxide; tert.-butylnitrite; water; hydrogen; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; sodium chloride; lithium hydroxide; 5% Pd(II)/C(eggshell); In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; toluene; acetonitrile;

Reference yield:

methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate (13544-07-5) → trans-2-[1-(2,4-dichloro-benzyl)-6-trifluoromethyl-1H-indazol-3-yl]-cyclopropanecarboxylic acid (877768-45-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: hydrogen / 5% Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr

2.1: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice

3.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 90 °C

4.1: diisobutylaluminium hydride / dichloromethane / 2.25 h / -78 °C / Inert atmosphere

4.2: -78 °C

5.1: manganese(IV) oxide / dichloromethane / 20 °C

6.1: dichloromethane / Reflux

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 40 °C

7.2: 0 °C / pH 2

8.1: zinc-copper couple / diethyl ether / 48 h / Reflux

With manganese(IV) oxide; tert.-butylnitrite; water; hydrogen; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; potassium carbonate; acetic acid; lithium hydroxide; 5% Pd(II)/C(eggshell); In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; acetonitrile;

upstream raw materials:

(E)-3-(1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid

diiodomethane

2-chloro-3-nitro-5-trifluoromethylbenzene

dimethyl 2-(2-nitro-4-trifluoromethylphenyl)malonate