Gamendazole

Base Information

Chemical Name:Gamendazole
CAS No.:877766-45-5
Molecular Formula:C18H11Cl2F3N2O2
Molecular Weight:415.199
Hs Code.:
UNII:X75Z3RSN5M
DSSTox Substance ID:DTXSID4042676
Nikkaji Number:J3.458.019G
Wikipedia:Gamendazole
Wikidata:Q5520039
ChEMBL ID:CHEMBL514569

Synonyms:gamendazole;trans-3-(1-benzyl-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid

Suppliers and Price of Gamendazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of Gamendazole

Chemical Property:

XLogP3:5.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:414.0149675
Heavy Atom Count:27
Complexity:575

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC2=C(C=C1C(F)(F)F)N(N=C2C=CC(=O)O)CC3=C(C=C(C=C3)Cl)Cl
Isomeric SMILES:C1=CC2=C(C=C1C(F)(F)F)N(N=C2/C=C/C(=O)O)CC3=C(C=C(C=C3)Cl)Cl

Technology Process of Gamendazole

There total 13 articles about Gamendazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

: 877773-21-2
1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazole-3-carbaldehyde

: 141-82-2
malonic acid

: 877766-45-5
(E)-3-(1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid

Guidance literature:: With piperidine; pyridine; at 65 ℃; for 2h;
DOI:10.1080/00397911.2012.696306

Reference yield: 90.0%

: 877773-31-4
3-[1-(2,4-Dichlorobenzyl)-6-trifluoromethyl-1H-indazol-3-yl]-acrylic acid ethyl ester

: 877766-45-5
(E)-3-(1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid

Guidance literature:: 3-[1-(2,4-Dichlorobenzyl)-6-trifluoromethyl-1H-indazol-3-yl]-acrylic acid ethyl ester; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 20 - 40 ℃; for 2 - 3h;

With sulfuric acid; at 0 ℃; pH=2;

Reference yield: 90.0%

: 877766-73-9
3-[1-(2,4-dichlorobenzyl)-6-trifluoromethyl-1H-indazol-3-yl]-acrylic acid ethyl ester

: 877766-45-5
(E)-3-(1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid

Guidance literature:: 3-[1-(2,4-dichlorobenzyl)-6-trifluoromethyl-1H-indazol-3-yl]-acrylic acid ethyl ester; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 40 ℃;

With sulfuric acid; In water; at 0 ℃; pH=2;