Methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate

Base Information

Chemical Name:Methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate
CAS No.:877773-17-6
Molecular Formula:C10H7F3N2O2
Molecular Weight:244.173
Hs Code.:2933990090
DSSTox Substance ID:DTXSID30696298
Wikidata:Q82625829
Mol file:877773-17-6.mol

Synonyms:877773-17-6;Methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate;6-TRIFLUOROMETHYL-1H-INDAZOLE-3-CARBOXYLIC ACID METHYL ESTER;SCHEMBL1050726;DTXSID30696298;AMY32404;CKB77317;MFCD09878903;SB39294;AS-71034;CS-0188776;FT-0756135;Methyl6-(trifluoromethyl)-1H-indazole-3-carboxylate;6-(Trifluoromethyl)1H-indazole-3-carboxylic acid methyl ester

Suppliers and Price of Methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
Methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate 96%
1 g
$ 1328.00

SynQuest Laboratories
Methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate 96%
250 mg
$ 491.00

J&W Pharmlab
6-Trifluoromethyl-1H-indazole-3-carboxylicacidmethylester 98%
500mg
$ 549.00

J&W Pharmlab
6-Trifluoromethyl-1H-indazole-3-carboxylicacidmethylester 98%
50mg
$ 156.00

Crysdot
Methyl6-(trifluoromethyl)-1H-indazole-3-carboxylate 95+%
5g
$ 1960.00

Crysdot
Methyl6-(trifluoromethyl)-1H-indazole-3-carboxylate 95+%
1g
$ 598.00

Chemenu
6-Trifluoromethyl-1H-indazole-3-carboxylicacidmethylester 95%
1g
$ 574.00

Apolloscientific
Methyl6-(trifluoromethyl)-1H-indazole-3-carboxylate
1g
$ 450.00

Apolloscientific
Methyl6-(trifluoromethyl)-1H-indazole-3-carboxylate
250mg
$ 175.00

American Custom Chemicals Corporation
6-TRIFLUOROMETHYL-1H-INDAZOLE-3-CARBOXYLIC ACID METHYL ESTER 96.00%
1G
$ 774.90

Total 13 raw suppliers

Chemical Property of Methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate

Chemical Property:

PSA：54.98000
LogP:2.36830
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:244.04596196
Heavy Atom Count:17
Complexity:308

Purity/Quality:

97% ^*data from raw suppliers

Methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate 96% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=NNC2=C1C=CC(=C2)C(F)(F)F

Technology Process of Methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate

There total 4 articles about Methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (2-acetylamino-4-trifluoromethylphenyl)-acetic acid methyl ester

: 877773-17-6
6-Trifluoromethyl-1H-indazole-3-carboxylic acid methyl ester

Guidance literature:: With tert.-butylnitrite; acetic acid; at 90 - 95 ℃; for 1.83333 - 2h;

Reference yield:

: 121-17-5
2-chloro-3-nitro-5-trifluoromethylbenzene

: 877773-17-6
6-Trifluoromethyl-1H-indazole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tert-butyl alcohol / Reflux

2: dimethyl sulfoxide; sodium chloride / water / 120 °C

3: hydrogen / 5% Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr

4: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice

With tert.-butylnitrite; potassium tert-butylate; hydrogen; acetic acid; dimethyl sulfoxide; sodium chloride; 5% Pd(II)/C(eggshell); In water; toluene; tert-butyl alcohol;

Reference yield:

: 290825-52-4
dimethyl 2-(2-nitro-4-trifluoromethylphenyl)malonate

: 877773-17-6
6-Trifluoromethyl-1H-indazole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dimethyl sulfoxide; sodium chloride / water / 120 °C

2: hydrogen / 5% Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr

3: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice

With tert.-butylnitrite; hydrogen; acetic acid; dimethyl sulfoxide; sodium chloride; 5% Pd(II)/C(eggshell); In water; toluene;