CHOLESTYRAMINE RESIN

Base Information

• Chemical Name: CHOLESTYRAMINE RESIN
• CAS No.: 11041-12-6
• Molecular Formula: Unspecified
• Molecular Weight: 385.66878
• Hs Code.: 3914002000
• Mol file: 11041-12-6.mol

Synonyms:Cholestyraminechloride;Cholestyramine hydroxide;Cholestyramine resin;Cholybar;Colestyramin;Cuemid;LoCholest;Quantalan;Questran Light;

Chemical Property of CHOLESTYRAMINE RESIN

Chemical Property:

• PSA: 0.00000
• LogP: 2.54390
• Solubility.: Insoluble in water, in methylene chloride and in ethanol (96 per cent).

Purity/Quality:

99%+ ^*data from raw suppliers

Cholestyramine(TechnicalGrade) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Indications: Cholestyramine: it is mainly used for the treatment of type Ⅱa hyperlipoproteinemia, especially in familial hypercholesterolemia. Also it is used for the treatment of primary biliary cirrhosis, drug-induced cholestatic jaundice itching, hypercholesterolemia, chronic cholecystitis, gallstones,Porphyrin thesaurismosis . Treatment of Atherosclerosis: 4~5g, 3 times/d. Itching: Start amount of 6~10g/d, maintenance dose of 3g/d,administration for 3 times . Long-term use can reduce intestinal binding bile salt ,and cause fat malabsorption, long-term use should add vitamin A, D, K and other fat-soluble vitamins and calcium appropriately , gastrointestinal responders may be appropriate with stomach medication. The above information is edited by the lookchem of Tian Ye. Cholestyramine is a powder that is mixed with water or another fluid before ingesting. Colestipol (Colestid) is another ion exchange resin that may be substituted in patients who find cholestyramine too constipating. Like charcoal, ion exchange resins may bind other orally administered drugs.
• Uses: Lipid-lowering drugs for type Ⅱ hyperlipidemia, atherosclerosis and other diseases. Antihyperlipidemic; ion-exchange resin (bile salts). Cholestyramine, like colestipol, binds bile acids, which are removed from the organism in a form bound to the ion-exchange resin. They are used for the same indications. Cholestyramine is used in biological study for current trends in anti-thyroid drug treatment of Graves disease. It is also used in pharmacological activity in treatment of capecitabine-induced enterocolitis.
• Clinical Use: Cholestyramine resin is the drug of choice for type IIa hyperlipoproteinemia.When used in conjunction with a controlleddiet, it reduces -lipoproteins. The drug is an insolublepolymer and, thus, probably one of the safest because itis not absorbed from the gastrointestinal tract to cause systemictoxic effects.
• Drug interactions: Potentially hazardous interactions with other drugs Anticoagulants: effect of coumarins and phenindione may be enhanced or reduced. Ciclosporin: may interact unpredictably with ciclosporin. Take ciclosporin at least 1 hour before or 4-6 hours after to prevent problems with absorption. Leflunomide: avoid concomitant use. Raloxifene, thyroid hormones, bile acids, valproate, cardiac glycosides and mycophenolate mofetil: absorption reduced.