2-PyridinecarboxaMide, 4-[(3-aMino-1,2,4-benzotriazin-7-yl)oxy]-N-Methyl-

Base Information

• Chemical Name: 2-PyridinecarboxaMide, 4-[(3-aMino-1,2,4-benzotriazin-7-yl)oxy]-N-Methyl-
• CAS No.: 877874-02-7
• Molecular Formula: C14H12N6O2
• Molecular Weight: 296.288
• Hs Code.: 2933990090
• Mol file: 877874-02-7.mol

Synonyms:

Chemical Property of 2-PyridinecarboxaMide, 4-[(3-aMino-1,2,4-benzotriazin-7-yl)oxy]-N-Methyl-

Chemical Property:

• PSA: 116.64000
• LogP: 1.47490
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

4-((3-Aminobenzo[e][1,2,4]triazin-7-yl)oxy)-N-methylpicolinamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-PyridinecarboxaMide, 4-[(3-aMino-1,2,4-benzotriazin-7-yl)oxy]-N-Methyl-

There total 1 articles about 2-PyridinecarboxaMide, 4-[(3-aMino-1,2,4-benzotriazin-7-yl)oxy]-N-Methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-amino-benzo[1,2,4]triazine-7-ol (877874-01-6) + 4-chloro-N-methylpicolinamide (220000-87-3) → 4-(3-amino-benzo[1,2,4]triazin-7-yloxy)pyridine-2-carboxylic acid methylamide (877874-02-7)

Guidance literature:

3-amino-benzo[1,2,4]triazine-7-ol; With potassium tert-butylate; In N,N-dimethyl-formamide; at 100 ℃; for 0.25h;

4-chloro-N-methylpicolinamide; With potassium carbonate; In N,N-dimethyl-formamide; at 140 ℃; for 0.5h;

Reference yield:

4-(3-amino-benzo[1,2,4]triazin-7-yloxy)pyridine-2-carboxylic acid methylamide (877874-02-7) + 1-Chloro-4-iodobenzene (637-87-6) + trifluoroacetic acid (76-05-1) → 4-[3-(4-chloro-phenylamino)-benzo[1,2,4]triazin-7-yloxy]-pyridine-2-carboxylic acid methylamide trifluoroacetate salt

Guidance literature:

4-(3-amino-benzo[1,2,4]triazin-7-yloxy)pyridine-2-carboxylic acid methylamide; 1-Chloro-4-iodobenzene; With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; In N,N-dimethyl-formamide; at 120 ℃; for 18h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

4-(3-amino-benzo[1,2,4]triazin-7-yloxy)pyridine-2-carboxylic acid methylamide (877874-02-7) + 5-bromo-2-chlorobenzotrifluoride (445-01-2) + trifluoroacetic acid (76-05-1) → 4-[3-(4-chloro-3-trifluoromethyl-phenylamino)-benzo[1,2,4]triazin-7-yloxy]-pyridine-2-carboxylic acid methylamide trifluoroacetate salt

Guidance literature:

4-(3-amino-benzo[1,2,4]triazin-7-yloxy)pyridine-2-carboxylic acid methylamide; 5-bromo-2-chlorobenzotrifluoride; With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; In N,N-dimethyl-formamide; at 120 ℃; for 18h;

trifluoroacetic acid; In water; acetonitrile;

upstream raw materials:

3-amino-benzo[1,2,4]triazine-7-ol

4-chloro-N-methylpicolinamide

Refernces