ATTACHMENT OF THE ANTHRAMYCIN ACRYLAMIDE SIDE CHAIN BY THE PALLADIUM CATALYZED COUPLING REACTION OF A VINYL TRFLATE

DOI: 10.1016/S0040-4039(00)96916-8

Source and publish data:

Tetrahedron Letters p. 6573 - 6576 (1987)

Update date:2022-09-26

Topics:

Authors:

Pena, Michael R.

Stille, J. K.

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Article abstract of DOI:10.1016/S0040-4039(00)96916-8

Conversion of the 2-keto group in the pyrrolo ring of pyrrolo(1,4)benzodiazepines to the vinyl triflate takes place regiospecifically to yield the enamine.The triflate undergoes palladium catalyzed coupling reactions to attach the acrylamide side chain.

Full text of DOI:10.1016/S0040-4039(00)96916-8

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