2-Bromo-4-(3-fluorophenylethynyl)thiazole

Base Information

Chemical Name:2-Bromo-4-(3-fluorophenylethynyl)thiazole
CAS No.:878018-74-7
Molecular Formula:C11H5BrFNS
Molecular Weight:282.136
Hs Code.:
UNII:VSS4MBV59P
ChEMBL ID:CHEMBL382491
DSSTox Substance ID:DTXSID80468225
Wikidata:Q82295356

Synonyms:2-bromo-4-(3-fluorophenylethynyl)thiazole;878018-74-7;VSS4MBV59P;UNII-VSS4MBV59P;CHEMBL382491;2-Bromanyl-4-(2-(3-fluorophenyl)ethynyl)-1,3-thiazole;2-Bromo-4-(2-(3-fluorophenyl)ethynyl)thiazole;Thiazole, 2-bromo-4-(2-(3-fluorophenyl)ethynyl)-;2-Bromo-4-[2-(3-fluorophenyl)ethynyl]thiazole;Thiazole, 2-bromo-4-[2-(3-fluorophenyl)ethynyl]-;SCHEMBL4145773;DTXSID80468225;BDBM50181781;AKOS015965444;PD180385

Suppliers and Price of 2-Bromo-4-(3-fluorophenylethynyl)thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Bromo-4-(3-fluorophenylethynyl)thiazole

Chemical Property:

XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:280.93101
Heavy Atom Count:15
Complexity:285

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC(=C1)F)C#CC2=CSC(=N2)Br

Technology Process of 2-Bromo-4-(3-fluorophenylethynyl)thiazole

There total 3 articles about 2-Bromo-4-(3-fluorophenylethynyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 878018-65-6
4-(3-fluoro-phenylethynyl)-thiazol-2-ylamine

: 878018-74-7
2-bromo-4-(3-fluoro-phenylethynyl)-thiazole

Guidance literature:: With tert.-butylnitrite; copper(ll) bromide; In acetonitrile; at 85 ℃; for 0.25h;
DOI:10.1021/jm050570f

Reference yield: 10.0%

: 878018-65-6
4-(3-fluoro-phenylethynyl)-thiazol-2-ylamine

: 878018-74-7
2-bromo-4-(3-fluoro-phenylethynyl)-thiazole

: C₁₁H₄Br₂FNS

Guidance literature:: With tert.-butylnitrite; copper(ll) bromide; In acetonitrile; at 85 ℃;
DOI:10.1021/jo802799c

Reference yield:

: 329203-88-5
4-(trimethylsilylethynyl)-2-thiazolylamine

: 878018-74-7
2-bromo-4-(3-fluoro-phenylethynyl)-thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / Pd(PPh₃)4; CuI; Et₃N / Bu₄NF / dimethylformamide; tetrahydrofuran / 0.25 h / 85 °C

2: 86 percent / tert-butyl nitrite; Cu(II)Br / acetonitrile / 0.25 h / 85 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; triethylamine; copper(ll) bromide; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1: modified Sonogashira coupling;
DOI:10.1021/jm050570f