Acetamide, 2-chloro-N-[(1S,2R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-[[( S)-(4-methylphenyl)sulfinyl]amino]-4-phenylbutyl]-N-(phenylmethyl)-

Base Information

Chemical Name:Acetamide, 2-chloro-N-[(1S,2R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-[[( S)-(4-methylphenyl)sulfinyl]amino]-4-phenylbutyl]-N-(phenylmethyl)-
CAS No.:878556-90-2
Molecular Formula:C33H45ClN2O3SSi
Molecular Weight:613.336
Hs Code.:

Acetamide,
2-chloro-N-[(1S,2R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-[[(
S)-(4-methylphenyl)sulfinyl]amino]-4-phenylbutyl]-N-(phenylmethyl)-

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Chemical Property of Acetamide, 2-chloro-N-[(1S,2R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-[[( S)-(4-methylphenyl)sulfinyl]amino]-4-phenylbutyl]-N-(phenylmethyl)-

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Technology Process of Acetamide, 2-chloro-N-[(1S,2R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-[[( S)-(4-methylphenyl)sulfinyl]amino]-4-phenylbutyl]-N-(phenylmethyl)-

There total 2 articles about Acetamide, 2-chloro-N-[(1S,2R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-[[( S)-(4-methylphenyl)sulfinyl]amino]-4-phenylbutyl]-N-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 878556-90-2
(+)-N-benzyl-N-[(1S,2R,S_S)-1-(t-butyldimethylsilyloxymethyl)-4-phenyl-2-(p-tolylsulfinylamino)but-1-yl]-2-chloroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / imidazole; DMAP / CH₂Cl₂ / 4 h / 20 °C

2: 83 percent / aq. NaHCO₃ / ethyl acetate / 24 h / 0 - 20 °C

With 1H-imidazole; dmap; sodium hydrogencarbonate; In dichloromethane; ethyl acetate;
DOI:10.1021/jo052077h

Reference yield:

: 467471-30-3
(-)-(2S,3R,S_S)-2-(benzylamino)-5-phenyl-3-(p-tolylsulfinylamino)pentan-1-ol

: 878556-90-2
(+)-N-benzyl-N-[(1S,2R,S_S)-1-(t-butyldimethylsilyloxymethyl)-4-phenyl-2-(p-tolylsulfinylamino)but-1-yl]-2-chloroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / imidazole; DMAP / CH₂Cl₂ / 4 h / 20 °C

2: 83 percent / aq. NaHCO₃ / ethyl acetate / 24 h / 0 - 20 °C

With 1H-imidazole; dmap; sodium hydrogencarbonate; In dichloromethane; ethyl acetate;
DOI:10.1021/jo052077h