2a,3,4,8b-Tetrahydronaphtho[1,2-b]azet-2(1H)-one

Base Information

Chemical Name:2a,3,4,8b-Tetrahydronaphtho[1,2-b]azet-2(1H)-one
CAS No.:59433-90-8
Molecular Formula:C₁₁H₁₁NO
Molecular Weight:173.214
Hs Code.:
NSC Number:174635
DSSTox Substance ID:DTXSID30974841
Nikkaji Number:J2.333.305H

Synonyms:59433-90-8;NSC174635;2a,3,4,8b-Tetrahydronaphtho[1,2-b]azet-2(1H)-one;1H,2H,2AH,3H,4H,8BH-NAPHTHO[1,2-B]AZET-2-ONE;2a,3,4,8b-Tetrahydronaphtho(1,2-b)azet-2(1H)-one;NSC 174635;2a,3,4,8b-tetrahydro-1H-naphtho[1,2-b]azet-2-one;SCHEMBL15609322;DTXSID30974841;RVCIXYMGIRZTFA-UHFFFAOYSA-N;AKOS015695002;NSC-174635;EN300-175016;2a,3,4,8b-Tetrahydronaphtho[1,2-b]azet-2-ol

Suppliers and Price of 2a,3,4,8b-Tetrahydronaphtho[1,2-b]azet-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2a,3,4,8b-Tetrahydronaphtho[1,2-b]azet-2(1H)-one

Chemical Property:

Vapor Pressure:1.39E-06mmHg at 25°C
Boiling Point:399.2°Cat760mmHg
Flash Point:235.2°C
Density:1.192g/cm³
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:173.084063974
Heavy Atom Count:13
Complexity:238

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=CC=CC=C2C3C1C(=O)N3

Technology Process of 2a,3,4,8b-Tetrahydronaphtho[1,2-b]azet-2(1H)-one

There total 1 articles about 2a,3,4,8b-Tetrahydronaphtho[1,2-b]azet-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189-71-5
isocyanate de chlorosulfonyle

: 447-53-0
1,2-Dihydronaphthalene

: 59433-90-8,5691-27-0
2a,3,4,8b-tetrahydronaphtho[1,2-b]azet-2(1H)-one

Guidance literature:: In diethyl ether;
DOI:10.1016/j.bmcl.2005.05.012

Reference yield:

: 59433-90-8,5691-27-0
2a,3,4,8b-tetrahydronaphtho[1,2-b]azet-2(1H)-one

: 1-[2-[(1-amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP; Et₃N / CH₂Cl₂

2: aq. LiOH / tetrahydrofuran

3: EDC; HOBT; NMM / CH₂Cl₂

4: HCl / CH₂Cl₂; dioxane

With 4-methyl-morpholine; hydrogenchloride; dmap; lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2005.05.012

Reference yield:

: 59433-90-8,5691-27-0
2a,3,4,8b-tetrahydronaphtho[1,2-b]azet-2(1H)-one

: 401843-49-0
{2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-chloro-benzyl)-2-oxo-ethylcarbamoyl]-1,2,3,4-tetrahydro-naphthalen-1-yl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP; Et₃N / CH₂Cl₂

2: aq. LiOH / tetrahydrofuran

3: EDC; HOBT; NMM / CH₂Cl₂

With 4-methyl-morpholine; dmap; lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.05.012