1H-Pyrrole-2-carboxylic acid, 5-[[[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]amino]carbonyl]-, phenylmethyl ester

Base Information

• Chemical Name: 1H-Pyrrole-2-carboxylic acid, 5-[[[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]amino]carbonyl]-, phenylmethyl ester
• CAS No.: 878627-28-2
• Molecular Formula: C19H22N4O5
• Molecular Weight: 386.407
• Mol file: 878627-28-2.mol

Synonyms:

Chemical Property of 1H-Pyrrole-2-carboxylic acid, 5-[[[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]amino]carbonyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole-2-carboxylic acid, 5-[[[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]amino]carbonyl]-, phenylmethyl ester

There total 2 articles about 1H-Pyrrole-2-carboxylic acid, 5-[[[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]amino]carbonyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-(benzyloxycarbonyl)-1H-pyrrole-2-carboxylic acid (848352-99-8) + tert-butyl carbamimidoylcarbamate (219511-71-4) → 5-((tert-butyloxycarbonyl)guanidiniocarbonyl)-1H-pyrrole-2-carboxylic acid benzyl ester (878627-28-2)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jo070981z

Reference yield:

C19H14N4O4 + tert-butyl carbamimidoylcarbamate (219511-71-4) → 5-((tert-butyloxycarbonyl)guanidiniocarbonyl)-1H-pyrrole-2-carboxylic acid benzyl ester (878627-28-2)

Guidance literature:

In N,N-dimethyl-formamide;

DOI:10.1002/ejoc.200700756

Reference yield:

5-((tert-butyloxycarbonyl)guanidiniocarbonyl)-1H-pyrrole-2-carboxylic acid benzyl ester (878627-28-2) + trifluoromethylsulfonic anhydride (358-23-6) → 5-[(tert-butoxycarbonylamino-trifluoromethanesulfonylimino-methyl)-carbamoyl]-1H-pyrrole-2-carboxylic acid benzyl ester

Guidance literature:

5-((tert-butyloxycarbonyl)guanidiniocarbonyl)-1H-pyrrole-2-carboxylic acid benzyl ester; With sodium hydride; In dichloromethane; at 0 ℃; for 1h;

trifluoromethylsulfonic anhydride; In dichloromethane; at -60 - 20 ℃; for 29h;

DOI:10.1021/ja056465c

upstream raw materials:

5-(benzyloxycarbonyl)-1H-pyrrole-2-carboxylic acid

tert-butyl carbamimidoylcarbamate

Downstream raw materials:

C₂₇H₃₆N₆O₈

C₂₅H₃₂N₄O₇

C₂₆H₃₄N₄O₇

C₆₀H₈₄N₁₀O₁₅