N-4-hydroxy-2'-deoxycytidylic acid

Base Information

Chemical Name:N-4-hydroxy-2'-deoxycytidylic acid
CAS No.:2277-58-9
Molecular Formula:C₉H₁₄N₃O₈P
Molecular Weight:323.199
Hs Code.:
Mol file:2277-58-9.mol

Synonyms:Cytidine,2'-deoxy-N-hydroxy-, 5'-(dihydrogen phosphate) (8CI); Cytidine,2'-deoxy-N-hydroxy-, 5'-phosphate (7CI); N4-Hydroxy-dCMP;N4-Hydroxydeoxycytidylic acid

Suppliers and Price of N-4-hydroxy-2'-deoxycytidylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N-4-hydroxy-2'-deoxycytidylic acid

Chemical Property:

Boiling Point:661.6°Cat760mmHg
Flash Point:353.9°C
Density:2.04g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of N-4-hydroxy-2'-deoxycytidylic acid

There total 4 articles about N-4-hydroxy-2'-deoxycytidylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1867-16-9
1-(β-D-2-deoxyribofuranosyl)-4-hydroxyaminopyrimidin-2(1H)-one

: 2277-58-9
1-(β-D-2-deoxyribofuranosyl)-4-hydroxyaminopyrimidin-2(1H)-one 5'-monophosphate

Guidance literature:: With tris(p-nitrophenyl)phosphate; wheat shoot nucleoside phosphotransferase; In acetate buffer; at 37 ℃; for 40h; pH=4.0;
DOI:10.1021/jm000975u

Reference yield:

: 109025-52-7
1-(3,5-Di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidinone

: 2277-58-9
1-(β-D-2-deoxyribofuranosyl)-4-hydroxyaminopyrimidin-2(1H)-one 5'-monophosphate

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / HONH₂*HCl; pyridine / 12 h / 20 °C

2: 81 percent / NH₃ / methanol / 12 h / 20 °C

3: 70 percent / p-nitrophenyl phosphate; wheat shoot nucleoside phosphotransferase / acetate buffer / 40 h / 37 °C / pH 4.0

With pyridine; tris(p-nitrophenyl)phosphate; wheat shoot nucleoside phosphotransferase; hydroxylamine hydrochloride; ammonia; In methanol; acetate buffer;
DOI:10.1021/jm000975u

Reference yield:

: 13030-62-1
3',5'-di-O-acetyl-2'-deoxyuridine

: 2277-58-9
1-(β-D-2-deoxyribofuranosyl)-4-hydroxyaminopyrimidin-2(1H)-one 5'-monophosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: POCl₃ / acetonitrile / 0.17 h / 0 °C

1.2: Et₃N / acetonitrile / 0.33 h / 0 °C

1.3: 91 percent / acetonitrile / 20 °C

2.1: 86 percent / HONH₂*HCl; pyridine / 12 h / 20 °C

3.1: 81 percent / NH₃ / methanol / 12 h / 20 °C

4.1: 70 percent / p-nitrophenyl phosphate; wheat shoot nucleoside phosphotransferase / acetate buffer / 40 h / 37 °C / pH 4.0

With pyridine; tris(p-nitrophenyl)phosphate; wheat shoot nucleoside phosphotransferase; hydroxylamine hydrochloride; ammonia; trichlorophosphate; In methanol; acetate buffer; acetonitrile;
DOI:10.1021/jm000975u