13030-62-1Relevant articles and documents
Synthesis of nucleoside-based antiviral drugs in ionic liquids
Kumar, Vineet,Malhotra, Sanjay V.
, p. 5640 - 5642 (2008)
Nucleoside-based antiviral drugs have been synthesized using imidazolium-based ionic liquids as reaction medium. The ionic liquids were proved to be better solvents for all the nucleoside in terms of solubility and reaction medium as compared to conventional molecular solvents.
Nucleic acid related compounds. 107. Efficient nitration of uracil base and nucleoside derivatives
Giziewicz, Jerzy,Wnuk, Stanislaw F.,Robins, Morris J.
, p. 2149 - 2151 (1999)
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5-iodo-4-thio-2′-deoxyuridine as a sensitizer of X-ray induced cancer cell killing
Makurat, Samanta,Spisz, Paulina,Kozak, Witold,Rak, Janusz,Zdrowowicz, Magdalena
, (2019)
Nucleosides, especially pyrimidines modified in the C5-position, can act as radiosensitizers via a mechanism that involves their enzymatic triphosphorylation, incorporation into DNA, and a subsequent dissociative electron attachment (DEA) process. In this paper, we report 5-iodo-4-thio-2′-deoxyuridine (ISdU) as a compound that can effectively lead to ionizing radiation (IR)-induced cellular death, which is proven by a clonogenic assay. The test revealed that the survival of cells, pre-treated with 10 or 100 μM solution of ISdU and exposed to 0.5 Gy of IR, was reduced from 78.4% (for non-treated culture) to 67.7% and to 59.8%, respectively. For a somewhat higher dose of 1 Gy, the surviving fraction was reduced from 68.2% to 54.9% and to 40.8% for incubation with 10 or 100 μM ISdU, respectively. The cytometric analysis of histone H2A.X phosphorylation showed that the radiosensitizing effect of ISdU was associated, at least in part, with the formation of double-strand breaks. Moreover, the cytotoxic test against the MCF-7 breast cancer cell line and human dermal fibroblasts (HDFa line) confirmed low cytotoxic activity of ISdU. Based on the results of steady state radiolysis of ISdU with a dose of 140 Gy and quantum chemical calculations explaining the origin of the MS detected radioproducts, the molecular mechanism of sensitization by ISdU was proposed. In conclusion, we found ISdU to be a potential radiosensitizer that could improve anticancer radiotherapy.
Biologically active glycosides from asteroidea, I. - Structures of a new cerebroside mixture and of two nucleosides from the starfish Acanthaster planci
Komori,Sanechika,Ito,et al.
, p. 653 - 668 (1980)
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5-Ethynyl-2′-deoxyuridine as a molecular probe of cell proliferation for high-content siRNA screening assay by "click" chemistry
Chen, Miaojuan,Qu, Dezhong,Chi, Weilin,Wang, Wei,Ren, Xiaoshuai,Cong, Shujie,Liang, Peizhou,Feng, Shipeng,Zhang, Biliang
, p. 1702 - 1710 (2011)
Labelling and identification of proliferating cells is important for the study of physiological or pathological processes in high-content screening (HCS) assays. Here we describe ethynyl deoxyuridine (EdU) as a biomarker for the assessment of cell proliferation and clearly demonstrate the feasibility of the EdU-labelling method for use in HCS assays. EdU detection is highly robust, reproducible, technically simple, and well suited for automated segmentation, which provides an excellent alternative for setting up multiplexed HCS assays of siRNA, miRNA and small-molecule libraries.
4 -thiouracil deoxynucleoside phosphate and application thereof in antiviral medicine
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Paragraph 0031-0034, (2021/10/16)
The invention discloses 4 -thiouracil deoxynucleoside phosphate and a structural formula thereof. Q06, discovery of new drug molecules not only has a new choice for treating hepatitis B, but also has important significance for developing more ideal hepatitis B drugs for treating hepatitis B.
